HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: CD244 (Q9BZW8)
Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
Gene: CD244

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.756

Property	Details
Experiments	11477068, 10358138, 15169881, 15841490, 16983070, 19150402, 15187115, 16920955, 26221972, 24642916, 11489943, 23346089
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, peptide array, surface plasmon resonance, pull down
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002250 - adaptive immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 370
+	Hs
		523136 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		CD244_HUMAN (1-370): 8.84e-97: 294: 100.00
+	Hs
		1271565 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		CD244_HUMAN (1-370): 8.84e-97: 294: 100.00
+	Hs
		412347 FYN_HUMAN (1-125): 4.91e-37: 133: 18.52		CD244_HUMAN (1-370): 8.84e-97: 294: 100.00
+	Hs
		789096 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		SLAF5_HUMAN (2-345): 8.99e-63: 205: 21.57
+	Mm
		1322348 SHIP1_MOUSE (4-103): 9.63e-37: 133: 42.00		SLAF1_MOUSE (6-325): 2.31e-60: 199: 19.41
+	Hs
		411818 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		SLAF6_HUMAN (2-332): 1.88e-56: 189: 18.71
+	Mm
		763408 FYN_MOUSE (1-125): 4.62e-37: 133: 18.52		SLAF1_MOUSE (6-325): 2.31e-60: 199: 19.41
+	Hs
		1271567 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		SLAF7_HUMAN (1-345): 9.95e-51: 174: 18.29
+	Hs
		523015 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		CEA21_HUMAN (6-280): 1.9e-50: 172: 16.78
+	Hs
		1271566 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		LY9_HUMAN (4-238): 1.56e-46: 169: 21.25
+	Hs
		1030743 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		SLAF1_HUMAN (1-324): 1.26e-48: 168: 19.29
+	Hs
		411561 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		CD48_HUMAN (28-247): 2.6e-46: 160: 22.42
+	Hs
		454828 FGR_HUMAN (1-126): 6.18e-38: 135: 20.30		SLAF1_HUMAN (1-324): 1.26e-48: 168: 19.29
+	Hs
		411547 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		CD2_HUMAN (9-356): 1.48e-44: 158: 13.24
+	Hs
		412176 FYN_HUMAN (1-125): 4.91e-37: 133: 18.52		SLAF1_HUMAN (1-324): 1.26e-48: 168: 19.29
+	Hs
		433317 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		CXAR_HUMAN (2-358): 7.84e-45: 159: 14.84
+	Hs
		433691 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		CXAR_HUMAN (2-358): 7.84e-45: 159: 14.84
+	Hs
		411939 FYN_HUMAN (1-125): 4.91e-37: 133: 18.52		CD2_HUMAN (9-356): 1.48e-44: 158: 13.24
+	Hs
		433742 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		PTK7_HUMAN (31-353): 1.31e-19: 92.7: 11.47
+	Dm
		219802 ABL_DROME (1-127): 2.37e-39: 141: 27.82		O44924_DROME (135-312): 8.74e-13: 71.9: 8.65