Protein: PWP2
Periodic tryptophan protein 2 (U three protein 1) (U3 small nucleolar RNA-associated protein 1) (U3 snoRNA-associated protein 1)

Gene: PWP2
Organism: Saccharomyces cerevisiae S288C
Interactions: 198
UniProt ID: P25635

Gene Ontology (top 5):
GO:0000028 - ribosomal small subunit assembly
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

635645

UTP21
U3 small nucleolar RNA-associated protein 21

16

16

Small-scale

0.987

High

635587

UTP18
U3 small nucleolar RNA-associated protein 18

14

2

Small-scale

0.983

High

635644

UTP13
U3 small nucleolar RNA-associated protein 13

13

17

Small-scale

0.981

High

635670

UTP12
U3 small nucleolar RNA-associated protein 12

11

15

Small-scale

0.981

High

635636

DHR1
Probable ATP-dependent RNA helicase DHR1

8

9

Small-scale

0.966

High

635582

UTP7
U3 small nucleolar RNA-associated protein 7

7

17

Small-scale

0.962

High

635637

UTP15
U3 small nucleolar RNA-associated protein 15

7

18

Small-scale

0.962

High

635654

UTP4
U3 small nucleolar RNA-associated protein 4

7

17

Small-scale

0.962

High

635565

DCA13
Protein SOF1

6

18

Small-scale

0.945

High

635651

RRP9
Ribosomal RNA-processing protein 9

6

18

High-throughput

0.945

High

635629

UTP17
NET1-associated nuclear protein 1

6

18

Small-scale

0.940

High

635633

HAS1
ATP-dependent RNA helicase HAS1

6

20

High-throughput

0.928

High

593593

DBP4
ATP-dependent RNA helicase HCA4

3

19

High-throughput

0.855

High

635572

DBP8
ATP-dependent RNA helicase DBP8

3

14

High-throughput

0.855

High

635597

ROK1
ATP-dependent RNA helicase ROK1

3

12

High-throughput

0.855

High

635611

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

3

6

High-throughput

0.855

High

481742

RS16B
Small ribosomal subunit protein uS9B

3

6

Small-scale

0.827

High

635635

UTP5
U3 small nucleolar RNA-associated protein 5

3

18

Small-scale

0.827

High

635628

UTP6
U3 small nucleolar RNA-associated protein 6

9

2

Small-scale

0.754

High

635652

NOC4
Nucleolar complex protein 4

10

7

Small-scale

0.754

High

635570

ENP1
Essential nuclear protein 1

10

2

Small-scale

0.752

High

635623

NAT10
RNA cytidine acetyltransferase

8

2

Small-scale

0.748

High

635602

MPP10
U3 small nucleolar RNA-associated protein MPP10

7

5

Small-scale

0.747

High

549340

FBRL
rRNA 2'-O-methyltransferase fibrillarin

7

10

Small-scale

0.745

High

635567

UTP20
U3 small nucleolar RNA-associated protein 20

7

1

Small-scale

0.745

High

635596

UTP10
U3 small nucleolar RNA-associated protein 10

7

5

High-throughput

0.745

High

635614

UTP22
U3 small nucleolar RNA-associated protein 22

7

3

Small-scale

0.745

High

635616

UTP8
U3 small nucleolar RNA-associated protein 8

7

1

Small-scale

0.745

High

635625

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

7

3

Small-scale

0.745

High

634507

KRR1
KRR1 small subunit processome component

6

2

Small-scale

0.732

High

635578

UTP9
U3 small nucleolar RNA-associated protein 9

6

1

High-throughput

0.732

High

635664

BMS1
Ribosome biogenesis protein BMS1

6

6

High-throughput

0.732

High

635674

NOP58
Nucleolar protein 58

6

11

Small-scale

0.732

High

635641

RRP5
rRNA biogenesis protein RRP5

6

11

Small-scale

0.730

High

635560

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

5

9

Small-scale

0.716

High

635568

RL1D1
Ribosome biogenesis protein UTP30

5

7

Small-scale

0.716

High

635649

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

5

1

Small-scale

0.716

High

635675

RRP12
Ribosomal RNA-processing protein 12

5

3

Small-scale

0.714

High

635604

NOL10
Ribosome biogenesis protein ENP2

5

3

Small-scale

0.712

High

635653

BFR2
Protein BFR2

5

3

Small-scale

0.712

High

635663

UTP16
U3 small nucleolar RNA-associated protein 16

5

1

Small-scale

0.712

High

635566

UTP11
U3 small nucleolar RNA-associated protein 11

5

1

High-throughput

0.703

High

635681

PNO1
Pre-rRNA-processing protein PNO1

4

1

Small-scale

0.697

High

635672

NOP56
Nucleolar protein 56

4

11

High-throughput

0.697

High

635551

RS5
Small ribosomal subunit protein uS7

4

2

Small-scale

0.694

High

635553

RS7A
Small ribosomal subunit protein eS7A

4

3

Small-scale

0.694

High

357913

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.691

High

535189

RS17B
Small ribosomal subunit protein eS17B

1

2

High-throughput

0.691

High

635680

NOP14
Nucleolar complex protein 14

4

3

High-throughput

0.691

High

635583

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

4

1

Small-scale

0.688

High

635619

ESF2
Pre-rRNA-processing protein ESF2

4

2

Small-scale

0.678

High

630454

RRP7
Ribosomal RNA-processing protein 7

4

1

Small-scale

0.676

High

141187

RS9A
Small ribosomal subunit protein uS4A

3

9

Small-scale

0.667

High

407761

RS13
Small ribosomal subunit protein uS15

3

3

Small-scale

0.667

High

635650

ESF1
Pre-rRNA-processing protein ESF1

3

1

High-throughput

0.662

High

413337

RS14A
Small ribosomal subunit protein uS11A

3

7

High-throughput

0.656

High

635591

FAF1
Protein FAF1

3

1

Small-scale

0.656

High

479693

RS4A
Small ribosomal subunit protein eS4A

3

3

Small-scale

0.640

High

480515

RS8A
Small ribosomal subunit protein eS8A

3

3

Small-scale

0.640

High

635620

CSL4
Exosome complex component CSL4

3

2

Small-scale

0.640

High

635658

RCL1
RNA 3'-terminal phosphate cyclase-like protein

3

1

Small-scale

0.640

High

407478

RS9B
Small ribosomal subunit protein uS4B

2

9

High-throughput

0.628

High

635594

DIM1
Dimethyladenosine transferase

3

0

High-throughput

0.628

High

470895

RS22A
Small ribosomal subunit protein uS8A

4

6

Small-scale

0.623

High

635558

MVD1
Diphosphomevalonate decarboxylase

2

1

High-throughput

0.621

High

635563

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

2

3

High-throughput

0.621

High

635548

PWP2
Periodic tryptophan protein 2

1

15

High-throughput

0.618

High

635549

SPB4
ATP-dependent rRNA helicase SPB4

1

19

High-throughput

0.618

High

635600

MTR4
ATP-dependent RNA helicase DOB1

1

17

High-throughput

0.618

High

635607

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.618

High

635613

EIF2A
Eukaryotic translation initiation factor 2A

1

2

High-throughput

0.618

High

635621

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

14

High-throughput

0.618

High

635666

SAS10
Something about silencing protein 10

2

2

High-throughput

0.614

High

406828

RS3
Small ribosomal subunit protein uS3

2

8

High-throughput

0.611

High

479417

RS24A
Small ribosomal subunit protein eS24A

2

3

Small-scale

0.611

High

635556

XPO1
Exportin-1

2

12

Small-scale

0.611

High

635564

RS3A1
Small ribosomal subunit protein eS1A

2

2

High-throughput

0.611

High

635580

RS14B
Small ribosomal subunit protein uS11B

2

7

Small-scale

0.611

High

635646

MRD1
Multiple RNA-binding domain-containing protein 1

2

5

Small-scale

0.611

High

635679

RS22B
Small ribosomal subunit protein uS8B

3

6

High-throughput

0.599

High

635577

YHS2
MIP18 family protein YHR122W

1

3

High-throughput

0.590

High

392318

H2A2
Histone H2A.2

3

7

High-throughput

0.587

High

635656

NOP6
Nucleolar protein 6

2

0

High-throughput

0.585

High

479955

RS6A
Small ribosomal subunit protein eS6A

2

6

Small-scale

0.584

High

481474

RS11B
Small ribosomal subunit protein uS17B

2

4

High-throughput

0.584

High

635588

RRT14
Regulator of rDNA transcription protein 14

2

1

Small-scale

0.584

High

635639

UTP14
U3 small nucleolar RNA-associated protein 14

2

4

High-throughput

0.584

High

635642

FCF1
rRNA-processing protein FCF1

2

1

Small-scale

0.584

High

635657

CMS1
Protein CMS1

2

1

High-throughput

0.584

High

635665

FCF2
rRNA-processing protein FCF2

2

2

Small-scale

0.584

High

635673

RRP36
rRNA biogenesis protein RRP36

2

1

Small-scale

0.584

High

415901

DED1
ATP-dependent RNA helicase DED1

1

8

High-throughput

0.575

High

635569

GBLP
Small ribosomal subunit protein RACK1

1

17

High-throughput

0.575

High

365880

HSP82
ATP-dependent molecular chaperone HSP82

2

9

High-throughput

0.571

High

534899

RL3
Large ribosomal subunit protein uL3

2

5

High-throughput

0.571

High

635638

BUD22
Bud site selection protein 22

2

2

High-throughput

0.571

High

357463

RLA4
Large ribosomal subunit protein P2B

2

1

High-throughput

0.567

High

619330

PSA3
Proteasome subunit alpha type-3

2

3

High-throughput

0.567

High

490481

HSP71
Heat shock protein SSA1

2

16

High-throughput

0.552

High

510426

SSB1
Ribosome-associated molecular chaperone SSB1

2

17

High-throughput

0.552

High

635584

SSB2
Ribosome-associated molecular chaperone SSB2

2

17

High-throughput

0.552

High

356281

H4
Histone H4

2

7

High-throughput

0.537

High

597291

PSA1
Proteasome subunit alpha type-1

2

2

High-throughput

0.537

High

635559

RML2
Large ribosomal subunit protein uL2m

2

2

High-throughput

0.537

High

635586

PSA4
Proteasome subunit alpha type-4

2

2

High-throughput

0.537

High

405138

RL17A
Large ribosomal subunit protein uL22A

1

3

High-throughput

0.536

High

613641

RS3A2
Small ribosomal subunit protein eS1B

1

2

High-throughput

0.536

High

635552

RL16B
Large ribosomal subunit protein uL13B

1

5

High-throughput

0.536

High

635595

YG4I
Uncharacterized GTP-binding protein YGR210C

1

2

High-throughput

0.536

High

481121

RL1A
Large ribosomal subunit protein uL1A

2

9

High-throughput

0.533

High

498813

RL4A
Large ribosomal subunit protein uL4A

2

6

High-throughput

0.521

High

471742

RL27A
Large ribosomal subunit protein eL27A

1

0

High-throughput

0.517

High

373460

PUR1
Amidophosphoribosyltransferase

1

1

High-throughput

0.515

High

635555

RL8B
Large ribosomal subunit protein eL8B

1

8

High-throughput

0.514

High

454206

TBA1
Tubulin alpha-1 chain

1

14

High-throughput

0.500

High

632976

MAS5
Mitochondrial protein import protein MAS5

1

10

High-throughput

0.500

High

404978

RL6B
Large ribosomal subunit protein eL6B

1

1

High-throughput

0.489

High

405958

RL33A
Large ribosomal subunit protein eL33A

1

3

High-throughput

0.489

High

406111

RL36A
Large ribosomal subunit protein eL36A

1

3

High-throughput

0.489

High

406296

RL15A
Large ribosomal subunit protein eL15A

1

3

High-throughput

0.489

High

635585

RL13B
Large ribosomal subunit protein eL13B

1

1

High-throughput

0.489

High

635612

RL26B
Large ribosomal subunit protein uL24B

1

6

High-throughput

0.489

High

635677

RL11B
Large ribosomal subunit protein uL5B

1

3

High-throughput

0.489

High

635605

GTO1
Glutathione S-transferase omega-like 1

1

0

High-throughput

0.486

High

479318

RS23B
Small ribosomal subunit protein uS12B

1

1

Small-scale

0.479

High

482113

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

606557

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.479

High

630166

RRP43
Exosome complex component RRP43

1

1

High-throughput

0.479

High

635550

RL5
Large ribosomal subunit protein uL18

1

3

Small-scale

0.479

High

635557

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

635561

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

635571

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

635573

CIC1
Proteasome-interacting protein CIC1

1

7

High-throughput

0.479

High

635575

RRP4
Exosome complex component RRP4

1

2

High-throughput

0.479

High

635576

LRP1
Exosome complex protein LRP1

1

1

High-throughput

0.479

High

635579

RRP8
25S rRNA

1

3

High-throughput

0.479

High

635589

UTP25
U3 small nucleolar RNA-associated protein 25

1

1

High-throughput

0.479

High

635592

RLP7
Ribosome biogenesis protein RLP7

1

6

High-throughput

0.479

High

635599

RRP41
Exosome complex component SKI6

1

11

High-throughput

0.479

High

635601

NOP9
Nucleolar protein 9

1

1

Small-scale

0.479

High

635603

URB2
Nucleolar pre-ribosomal-associated protein 2

1

1

High-throughput

0.479

High

635606

MTR3
Exosome complex component MTR3

1

1

High-throughput

0.479

High

635608

RL4B
Large ribosomal subunit protein uL4B

1

6

High-throughput

0.479

High

635615

RRP46
Exosome complex component RRP46

1

11

High-throughput

0.479

High

635618

PXR1
Protein PXR1

1

1

Small-scale

0.479

High

635624

APJ1
J domain-containing protein APJ1

1

9

High-throughput

0.479

High

635627

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

635630

ESP1
Separin

1

1

High-throughput

0.479

High

635632

TOM1
E3 ubiquitin-protein ligase TOM1

1

8

High-throughput

0.479

High

635634

BUL2
Ubiquitin ligase-binding protein BUL2

1

2

Small-scale

0.479

High

635643

RRP45
Exosome complex component RRP45

1

8

High-throughput

0.479

High

635647

SGD1
Suppressor of glycerol defect protein 1

1

4

High-throughput

0.479

High

635655

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.479

High

635659

RRP44
Exosome complex exonuclease DIS3

1

3

High-throughput

0.479

High

635660

BRX1
Ribosome biogenesis protein BRX1

1

5

High-throughput

0.479

High

635661

RRP40
Exosome complex component RRP40

1

1

High-throughput

0.479

High

635662

SGO1
Shugoshin

1

2

High-throughput

0.479

High

635667

RRP6
Exosome complex exonuclease RRP6

1

5

High-throughput

0.479

High

635668

MAK21
Ribosome biogenesis protein MAK21

1

7

High-throughput

0.479

High

635671

RRP42
Exosome complex component RRP42

1

8

High-throughput

0.479

High

635676

EFG1P
rRNA-processing protein EFG1

1

1

High-throughput

0.479

High

635617

NOP19
Nucleolar protein 19

1

0

Small-scale

0.458

High

635678

RS28A
Small ribosomal subunit protein eS28A

1

0

Small-scale

0.458

High

341943

ATPB
ATP synthase subunit beta, mitochondrial

1

6

High-throughput

0.457

High

378300

LEU3
3-isopropylmalate dehydrogenase

1

5

High-throughput

0.457

High

583202

METK2
S-adenosylmethionine synthase 2

1

2

High-throughput

0.457

High

367787

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

376655

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

3

High-throughput

0.445

High

399348

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.445

High

404511

RL7A
Large ribosomal subunit protein uL30A

1

6

High-throughput

0.445

High

425800

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.445

High

493321

HSP72
Heat shock protein SSA2

1

16

High-throughput

0.445

High

555847

VATB
V-type proton ATPase subunit B

1

6

High-throughput

0.445

High

628919

SCJ1
DnaJ-related protein SCJ1

1

6

High-throughput

0.445

High

635574

SSZ1
Ribosome-associated complex subunit SSZ1

1

13

High-throughput

0.445

High

635598

RSSA2
Small ribosomal subunit protein uS2B

1

2

High-throughput

0.445

High

635609

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

2

High-throughput

0.445

High

635610

IMB5
Importin subunit beta-5

1

1

High-throughput

0.445

High

635622

PFD4
Prefoldin subunit 4

1

4

High-throughput

0.445

High

635669

RL7B
Large ribosomal subunit protein uL30B

1

6

High-throughput

0.445

High

382979

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.437

High

405464

RL26A
Large ribosomal subunit protein uL24A

1

6

High-throughput

0.437

High

472047

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.437

High

481293

RL2A
Large ribosomal subunit protein uL2A

1

2

High-throughput

0.437

High

482671

RL19B
Large ribosomal subunit protein eL19

1

1

High-throughput

0.437

High

628652

CANB
Calcineurin subunit B

1

4

High-throughput

0.437

High

635554

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

635562

SC61A
Protein transport protein SEC61

1

1

High-throughput

0.437

High

635581

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

635590

ULP2
Ubiquitin-like-specific protease 2

1

7

High-throughput

0.437

High

635626

NUM1
Nuclear migration protein NUM1

1

15

High-throughput

0.437

High

635648

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

627738

SIS1
Protein SIS1

1

6

High-throughput

0.407

High

635631

ERO1
Endoplasmic oxidoreductin-1

2

0

High-throughput

0.324

High

397580

OTC
Ornithine carbamoyltransferase

1

0

High-throughput

0.261

Low

635640

SOV1
Protein SOV1, mitochondrial

1

0

High-throughput

0.261

Low

635593

LYS14
Lysine biosynthesis regulatory protein LYS14

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024