HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: DOK1 (Q99704)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
Gene: DOK1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	10852966
Identification Methods	pull down, affinity chromatography technology, coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 481
+	Hs
		442876 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		789086 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		337542 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		433460 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		433966 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Mm
		337623 ABL1_MOUSE (1-127): 5.17e-40: 143: 26.72		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Mm
		639441 LYN_MOUSE (1-125): 1.07e-39: 140: 19.85		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Mm
		337639 ABL1_MOUSE (1-127): 5.17e-40: 143: 26.72		DOK3_MOUSE (1-458): 4.81e-120: 360: 30.90
+	Mm
		250948 ABL1_MOUSE (1-127): 5.17e-40: 143: 26.72		DOK2_MOUSE (2-426): 3.12e-118: 354: 31.31
+	Mm
		250950 LYN_MOUSE (1-125): 1.07e-39: 140: 19.85		DOK2_MOUSE (2-426): 3.12e-118: 354: 31.31
+	Hs
		235031 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		235035 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Mm
		250949 SRC_MOUSE (1-127): 8.71e-39: 138: 20.90		DOK2_MOUSE (2-426): 3.12e-118: 354: 31.31
+	Hs
		235037 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		151689 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Hs
		151692 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Mm
		639440 LYN_MOUSE (1-125): 1.07e-39: 140: 19.85		IRS2_MOUSE (6-371): 1.55e-70: 245: 15.10
+	Hs
		411805 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		FRS2_HUMAN (154-464): 2.53e-54: 191: 21.09
+	Hs
		207290 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		FRS3_HUMAN (153-432): 4e-52: 185: 20.42
+	Hs
		433914 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		FRS2_HUMAN (154-464): 2.53e-54: 191: 21.09