HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: LY9 (Q9HBG7)
T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229)
Gene: LY9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.50	0.632

Property	Details
Experiments	11389028, 11477068, 19150402, 26221972
Identification Methods	affinity chromatography technology, two hybrid, peptide array, surface plasmon resonance
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 655
+	Hs
		1271566 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		LY9_HUMAN (1-655): 1.6e-147: 444: 100.00
+	Hs
		434019 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		ROBO2_HUMAN (2-651): 7.02e-66: 237: 12.66
+	Hs
		789096 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		SLAF5_HUMAN (33-244): 1.73e-60: 207: 38.01
+	Hs
		1271567 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		SLAF7_HUMAN (243-538): 2.12e-60: 207: 27.12
+	Hs
		434111 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		ROBO1_HUMAN (2-651): 1.22e-50: 192: 10.72
+	Hs
		411818 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		SLAF6_HUMAN (32-254): 9.4e-51: 180: 32.47
+	Hs
		1030743 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		SLAF1_HUMAN (25-263): 4.62e-43: 160: 24.41
+	Hs
		454828 FGR_HUMAN (1-126): 6.18e-38: 135: 20.30		SLAF1_HUMAN (25-263): 4.62e-43: 160: 24.41
+	Hs
		411547 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		CD2_HUMAN (247-582): 7.92e-38: 145: 20.17
+	Hs
		297880 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		NFASC_HUMAN (210-611): 4.22e-24: 110: 9.89
+	Hs
		523015 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		CEA21_HUMAN (13-239): 4.37e-27: 113: 19.36
+	Hs
		433507 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		TUTLB_HUMAN (24-471): 5.62e-20: 97: 12.14
+	Hs
		434081 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		TUTLB_HUMAN (24-471): 5.62e-20: 97: 12.14
+	Hs
		523211 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		TUTLB_HUMAN (24-471): 5.62e-20: 97: 12.14
+	Hs
		411561 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		CD48_HUMAN (60-243): 2.02e-18: 86.9: 19.57
+	Hs
		523136 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		CD244_HUMAN (44-379): 3.34e-14: 76.5: 17.31
+	Hs
		433569 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		CD22_HUMAN (253-637): 5.7e-13: 74.3: 12.07
+	Mm
		722908 SHIP1_MOUSE (4-103): 9.63e-37: 133: 42.00		CD22_MOUSE (61-431): 4.56e-15: 81.1: 17.40
+	Hs
		1271565 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		CD244_HUMAN (44-379): 3.34e-14: 76.5: 17.31
+	Hs
		590610 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		CD22_HUMAN (253-637): 5.7e-13: 74.3: 12.07