HitPredict

Interactor 1: TBL1X (O60907)
F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked)
Gene: TBL1X

Interactor 2: NCOR2 (Q9Y618)
Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)
Gene: NCOR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.726

Property	Details
Experiments	12628926, 12502735, 10944117, 10809664, 21240272
Identification Methods	affinity chromatography technology, pull down, biochemical, two hybrid, fluorescence polarization spectroscopy
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0017053 - transcription repressor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 577 Hs			1 2514
+	Hs
		1309170 TBL1Y_HUMAN (309-577): 1.63e-61: 213: 20.41		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		1346974 NLE1_HUMAN (12-397): 3.64e-50: 182: 12.87		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Xl
		1093463 TB1RA_XENLA (52-577): 9.6e-159: 465: 86.34		Q1W3Z6_XENLA (4-2514): 7.45e-150: 523: 51.60
+	Hs
		245548 TBL1X_HUMAN (1-577): 0: 532: 100.00		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		261584 TBL1R_HUMAN (52-577): 1.43e-158: 465: 84.25		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Xl
		1186358 TB1RA_XENLA (52-577): 9.6e-159: 465: 86.34		NCOR1_XENLA (1-2514): 7.28e-122: 434: 32.87
+	Hs
		245648 TBL1X_HUMAN (1-577): 0: 532: 100.00		RCOR1_HUMAN (388-705): 2.51e-45: 174: 22.05
+	Hs
		261578 TBL1Y_HUMAN (309-577): 1.63e-61: 213: 20.41		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Mm
		1206786 TBL1X_MOUSE (52-577): 1.02e-160: 470: 93.93		Q8BK32_MOUSE (1-280): 1.47e-40: 155: 49.66
+	Mm
		1206586 TBL1R_MOUSE (52-577): 1.06e-159: 467: 84.25		Q8BK32_MOUSE (1-280): 1.47e-40: 155: 49.66
+	Hs
		261563 SNR40_HUMAN (66-313): 1.45e-26: 113: 10.32		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		793042 LIS1_HUMAN (51-493): 5.94e-96: 300: 17.74		SRRM2_HUMAN (11-1905): 4.06e-30: 133: 8.95
+	Hs
		1281467 FBXW7_HUMAN (356-576): 5.94e-55: 199: 24.32		RCOR1_HUMAN (388-705): 2.51e-45: 174: 22.05
+	Hs
		1346970 NLE1_HUMAN (12-397): 3.64e-50: 182: 12.87		SRRM2_HUMAN (11-1905): 4.06e-30: 133: 8.95
+	Hs
		903450 WDR5_HUMAN (363-577): 1.41e-66: 221: 28.44		CIC_HUMAN (7-2131): 8.47e-18: 93.5: 9.33
+	Hs
		903374 WDR5_HUMAN (363-577): 1.41e-66: 221: 28.44		KMT2C_HUMAN (679-1264): 4.24e-16: 88: 11.93
+	Hs
		1302927 NLE1_HUMAN (12-397): 3.64e-50: 182: 12.87		MINT_HUMAN (80-1321): 6.8e-20: 100: 8.11
+	Hs
		1281391 FBXW7_HUMAN (356-576): 5.94e-55: 199: 24.32		PRR36_HUMAN (2-1025): 1.03e-10: 69.6: 8.95
+	Hs
		1288258 SNR40_HUMAN (66-313): 1.45e-26: 113: 10.32		MINT_HUMAN (80-1321): 6.8e-20: 100: 8.11
+	Hs
		1264784 SNR40_HUMAN (66-313): 1.45e-26: 113: 10.32		TITIN_HUMAN (1125-2056): 5.55e-11: 70.9: 8.61