HitPredict

Interactor 1: PHLP1 (O60346)
PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
Gene: PHLPP1

Interactor 2: TLN1 (Q9Y490)
Talin-1
Gene: TLN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	33397691
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	IRS~PH
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1717 Hs			1 2541
+	Hs
		247233 PHLP1_HUMAN (1-1717): 0: 1481: 100.00		MOES_HUMAN (163-404): 1.94e-51: 195: 23.05
+	Hs
		247333 PHLP1_HUMAN (1-1717): 0: 1481: 100.00		GOGB1_HUMAN (243-2541): 1.91e-45: 184: 8.51
+	Hs
		247335 PHLP1_HUMAN (1-1717): 0: 1481: 100.00		PLEC_HUMAN (916-2528): 1.86e-24: 115: 11.40
+	Hs
		247404 PHLP1_HUMAN (1-1717): 0: 1481: 100.00		FERM2_HUMAN (268-416): 1.7e-11: 72: 27.82
+	Hs
		1209835 LRRK2_HUMAN (716-1019): 5.98e-18: 93.2: 29.32		TLN1_HUMAN (1-2541): 0: 1185: 100.00
+	Hs
		582849 PHLP2_HUMAN (438-866): 2.09e-47: 189: 17.88		EZRI_HUMAN (84-666): 3.04e-82: 285: 14.65
+	Hs
		767462 PHLP2_HUMAN (438-866): 2.09e-47: 189: 17.88		RADI_HUMAN (163-404): 6.21e-57: 211: 22.27
+	Hs
		1413651 LRRC1_HUMAN (896-1143): 8.95e-09: 62: 28.74		E41L5_HUMAN (50-686): 3.66e-95: 328: 13.83
+	Hs
		73618 LRRK2_HUMAN (716-1019): 5.98e-18: 93.2: 29.32		B2R6J2_HUMAN (84-666): 3.47e-82: 285: 14.65
+	Hs
		582929 ERBIN_HUMAN (637-806): 2.74e-09: 64.3: 26.86		EZRI_HUMAN (84-666): 3.04e-82: 285: 14.65
+	Hs
		72883 LRRK2_HUMAN (716-1019): 5.98e-18: 93.2: 29.32		B0YJ88_HUMAN (163-404): 6.21e-57: 211: 22.27
+	Hs
		683853 LRRK2_HUMAN (716-1019): 5.98e-18: 93.2: 29.32		MOES_HUMAN (163-404): 1.94e-51: 195: 23.05
+	Hs
		1132269 LRRK2_HUMAN (716-1019): 5.98e-18: 93.2: 29.32		GOGB1_HUMAN (243-2541): 1.91e-45: 184: 8.51
+	Hs
		1143147 LRRK2_HUMAN (716-1019): 5.98e-18: 93.2: 29.32		PLEC_HUMAN (916-2528): 1.86e-24: 115: 11.40
+	Hs
		1209486 LRRK2_HUMAN (716-1019): 5.98e-18: 93.2: 29.32		FERM2_HUMAN (268-416): 1.7e-11: 72: 27.82
+	Hs
		1209782 LRRK2_HUMAN (716-1019): 5.98e-18: 93.2: 29.32		MYH2_HUMAN (2033-2538): 2.32e-10: 68.7: 11.11
+	Hs
		1040361 ERBIN_HUMAN (637-806): 2.74e-09: 64.3: 26.86		DYST_HUMAN (372-2531): 7.74e-18: 93.8: 8.71