HitPredict

Interactor 1: NCOR1 (O75376)
Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)
Gene: NCOR1

Interactor 2: RARG (P13631)
Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3)
Gene: RARG

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	10336495
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2440 Hs			1 454
+	Hs
		261381 NCOR1_HUMAN (1-2440): 0: 780: 100.00		RARA_HUMAN (1-426): 2.76e-129: 383: 74.41
+	Hs
		261399 NCOR1_HUMAN (1-2440): 0: 780: 100.00		RXRA_HUMAN (4-422): 3.64e-127: 378: 30.00
+	Hs
		261383 NCOR1_HUMAN (1-2440): 0: 780: 100.00		THB_HUMAN (35-418): 3.58e-115: 347: 33.17
+	Hs
		261369 NCOR1_HUMAN (1-2440): 0: 780: 100.00		ESR1_HUMAN (2-448): 6.96e-112: 343: 22.02
+	Hs
		261429 NCOR1_HUMAN (1-2440): 0: 780: 100.00		HNF4A_HUMAN (57-423): 2e-110: 336: 25.54
+	Hs
		261493 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR1H3_HUMAN (1-420): 1.18e-105: 322: 28.25
+	Hs
		261450 NCOR1_HUMAN (1-2440): 0: 780: 100.00		NR1H2_HUMAN (10-420): 1.15e-104: 320: 29.65
+	Hs
		261557 NCOR1_HUMAN (1-2440): 0: 780: 100.00		ESR2_HUMAN (7-451): 2.68e-102: 316: 23.37
+	Hs
		261382 NCOR1_HUMAN (1-2440): 0: 780: 100.00		THA_HUMAN (90-394): 5.24e-64: 216: 37.13
+	Hs
		261481 NCOR1_HUMAN (1-2440): 0: 780: 100.00		PPARA_HUMAN (65-418): 1.7e-49: 177: 30.20
+	Hs
		261424 NCOR1_HUMAN (1-2440): 0: 780: 100.00		PPARG_HUMAN (90-418): 2.61e-47: 171: 31.52
+	Hs
		261474 NCOR1_HUMAN (1-2440): 0: 780: 100.00		PPARD_HUMAN (90-418): 1.46e-47: 171: 30.27
+	Hs
		500380 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		RARB_HUMAN (1-453): 8.27e-140: 410: 72.03
+	Mm
		723171 NCOR1_MOUSE (1-2440): 0: 701: 89.79		PPARD_MOUSE (90-418): 8.48e-47: 169: 30.54
+	Hs
		488042 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		RARA_HUMAN (1-426): 2.76e-129: 383: 74.41
+	Xl
		574911 NCOR1_XENLA (1-2440): 1.54e-154: 538: 62.28		THBA_XENLA (72-418): 1.24e-102: 312: 35.12
+	Xl
		546251 NCOR1_XENLA (1-2440): 1.54e-154: 538: 62.28		THAA_XENLA (55-420): 1.56e-101: 311: 35.71
+	Hs
		500510 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		THB_HUMAN (35-418): 3.58e-115: 347: 33.17
+	Hs
		370824 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		ESR1_HUMAN (2-448): 6.96e-112: 343: 22.02
+	Hs
		500454 NCOR2_HUMAN (1-2439): 6.74e-134: 473: 34.71		THA_HUMAN (90-394): 5.24e-64: 216: 37.13