HitPredict - High confidence protein-protein interactions

Interactor 1: AXIN1 (O70239)
Axin-1 (Axis inhibition protein 1) (rAxin)
Gene: AXIN1

Interactor 2: APC (P70478)
Adenomatous polyposis coli protein (Protein APC)
Gene: APC

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16815997
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Arm~Axin_b-cat_bind, RGS~SAMP
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005938 - cell cortex GO:0006915 - apoptotic process and 17 others more... GO:0008013 - beta-catenin binding GO:0009953 - dorsal/ventral pattern formation GO:0015630 - microtubule cytoskeleton GO:0016055 - Wnt signaling pathway GO:0016328 - lateral plasma membrane GO:0019901 - protein kinase binding GO:0030163 - protein catabolic process GO:0030178 - negative regulation of Wnt signaling pathway GO:0030877 - beta-catenin destruction complex GO:0031122 - cytoplasmic microtubule organization GO:0031625 - ubiquitin protein ligase binding GO:0032991 - protein-containing complex GO:0045732 - positive regulation of protein catabolic process GO:0048471 - perinuclear region of cytoplasm GO:0060070 - canonical Wnt signaling pathway GO:0065003 - protein-containing complex assembly GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1	827
Rn

1	2842

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Last updated: 11Aug2025