HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.713

Property	Details
Experiments	30737378, 10581039, 24457600, 24981860, 11124122
Identification Methods	affinity chromatography technology, pull down, two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035098 - ESC/E(Z) complex GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 441 Hs			1 488
+	Hs
		245623 TBL1X_HUMAN (13-441): 1.12e-73: 243: 11.39		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		140307 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		268072 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Dm
		1276541 Q9VKD5_DROME (1-440): 2.91e-80: 257: 49.89		HDAC1_DROME (5-472): 0: 653: 77.92
+	Hs
		1270423 TBL1R_HUMAN (4-335): 2.6e-56: 195: 11.40		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		245600 TBL1X_HUMAN (13-441): 1.12e-73: 243: 11.39		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038686 TBL1R_HUMAN (4-335): 2.6e-56: 195: 11.40		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1270358 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		177148 TBL1X_HUMAN (13-441): 1.12e-73: 243: 11.39		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		1270370 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		903404 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		177377 TBL1R_HUMAN (4-335): 2.6e-56: 195: 11.40		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		903202 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Dm
		1097598 ESC_DROME (23-226): 5.01e-10: 63: 8.10		HDAC1_DROME (5-472): 0: 653: 77.92
+	Hs
		177369 TBL1Y_HUMAN (277-439): 5.06e-19: 91.1: 13.33		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		177249 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		245622 TBL1X_HUMAN (13-441): 1.12e-73: 243: 11.39		HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37
+	Hs
		1260185 TBL1R_HUMAN (4-335): 2.6e-56: 195: 11.40		HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37
+	Hs
		1260173 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37