HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: EZH1 (Q92800)
Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1)
Gene: EZH1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.977

Property	Details
Experiments	28320739, 27705803, 32296183, 24981860, 19026781, 9584197, 33961781, 19026780, 9566901, unassigned1304, 20211142
Identification Methods	affinity chromatography technology, two hybrid, pull down, validated two hybrid, tandem affinity purification, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	EZH2_WD-Binding~WD40, SET~WD40
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031491 - nucleosome binding GO:0035098 - ESC/E(Z) complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 Hs			1 747
+	Mm
		936654 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		EZH1_MOUSE (1-747): 0: 862: 97.86
+	Mm
		1142289 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		EZH2_MOUSE (8-746): 0: 724: 63.04
+	Hs
		268116 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		EZH2_HUMAN (8-746): 0: 719: 62.78
+	Mm
		1149787 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		Q6AXH7_MOUSE (8-746): 0: 701: 62.24
+	Dm
		785644 Q9VKD5_DROME (1-440): 2.91e-80: 257: 49.89		EZ_DROME (8-747): 0: 693: 49.56
+	Dm
		785633 Q95SW6_DROME (253-440): 2.14e-61: 199: 58.51		EZ_DROME (8-747): 0: 693: 49.56
+	Hs
		1080207 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		EZH2_HUMAN (8-746): 0: 719: 62.78
+	Ce
		184559 MES6_CAEEL (78-440): 4.44e-85: 269: 24.13		MES2_CAEEL (109-737): 1.4e-120: 381: 24.81
+	Mm
		1265660 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		EHMT2_MOUSE (419-733): 2.05e-74: 264: 23.38
+	Hs
		268228 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		EHMT2_HUMAN (419-733): 7.51e-74: 262: 23.10
+	Hs
		268290 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		EHMT1_HUMAN (416-733): 2.04e-73: 261: 21.88
+	Zm
		35725 A0A1D6LQJ4_MAIZE (221-441): 3.05e-27: 112: 15.25		A0A1D6M742_MAIZE (232-734): 6.96e-131: 405: 14.24
+	Mm
		1207353 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		NSD2_MOUSE (471-730): 1.85e-61: 226: 23.72
+	Mm
		93750 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		E9QAE4_MOUSE (472-730): 1.46e-54: 206: 23.55
+	Hs
		1281314 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		EHMT2_HUMAN (419-733): 7.51e-74: 262: 23.10
+	Hs
		331862 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		NSD2_HUMAN (471-730): 3.64e-61: 225: 24.09
+	At
		1319861 WDR5A_ARATH (185-440): 5.1e-47: 166: 15.00		ATX1_ARATH (612-729): 2.01e-18: 92.4: 39.67
+	Hs
		975303 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		KMT2A_HUMAN (620-734): 4.36e-19: 95.1: 42.24
+	Dm
		1129076 WDS_DROME (267-440): 1.02e-23: 103: 15.34		SET1_DROME (612-733): 3.98e-19: 94.7: 39.52
+	Hs
		975304 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		KMT2A_HUMAN (620-734): 4.36e-19: 95.1: 42.24