HitPredict

Interactor 1: SKAP2 (O75563)
Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains)
Gene: SKAP2

Interactor 2: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.917

Property	Details
Experiments	29568343, 9837776, 32707033, 12893833, unassigned1973
Identification Methods	protein complementation assay, affinity chromatography technology, enzymatic study, two hybrid fragment pooling approach, pull down
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1, PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 359 Hs			1 537
+	Mm
		763391 SKAP2_MOUSE (1-359): 1.56e-121: 356: 90.53		FYN_MOUSE (1-537): 0: 642: 99.44
+	Hs
		269517 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		SRC_HUMAN (1-537): 0: 598: 68.21
+	Hs
		269512 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		YES_HUMAN (1-537): 0: 591: 71.61
+	Hs
		412249 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		FYN_HUMAN (1-537): 0: 643: 100.00
+	Hs
		269515 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		FGR_HUMAN (1-536): 0: 581: 69.82
+	Mm
		411926 SKAP2_MOUSE (1-359): 1.56e-121: 356: 90.53		LCK_MOUSE (40-535): 0: 553: 57.20
+	Hs
		269510 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		LCK_HUMAN (40-535): 0: 551: 57.60
+	Hs
		269514 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		HCK_HUMAN (1-535): 0: 548: 56.64
+	Hs
		523046 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		SRC_HUMAN (1-537): 0: 598: 68.21
+	Mm
		639444 SKAP2_MOUSE (1-359): 1.56e-121: 356: 90.53		LYN_MOUSE (1-535): 0: 535: 53.92
+	Hs
		269513 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		LYN_HUMAN (1-535): 0: 535: 54.48
+	Hs
		269523 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		BLK_HUMAN (28-532): 2.42e-179: 515: 56.72
+	Hs
		269519 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		FRK_HUMAN (77-529): 6.35e-176: 507: 52.26
+	Hs
		411781 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		LCK_HUMAN (40-535): 0: 551: 57.60
+	Hs
		433867 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		LYN_HUMAN (1-535): 0: 535: 54.48
+	Hs
		269541 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		SRMS_HUMAN (50-528): 3.37e-152: 446: 39.00
+	Hs
		433388 PKHA7_HUMAN (26-316): 3.97e-42: 159: 14.52		YES_HUMAN (1-537): 0: 591: 71.61
+	Hs
		411764 PKHA7_HUMAN (26-316): 3.97e-42: 159: 14.52		LCK_HUMAN (40-535): 0: 551: 57.60
+	Hs
		411861 PKHA5_HUMAN (27-326): 3.7e-39: 150: 15.86		LCK_HUMAN (40-535): 0: 551: 57.60
+	Hs
		433831 PKHA7_HUMAN (26-316): 3.97e-42: 159: 14.52		LYN_HUMAN (1-535): 0: 535: 54.48