Protein: S100B
Protein S100-B (S-100 protein beta chain) (S-100 protein subunit beta) (S100 calcium-binding protein B)

Gene: S100B
Organism: Homo sapiens
Interactions: 206
UniProt ID: P04271

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

407580

S10A1
Protein S100-A1

12

17

Small-scale

0.986

High

407557

S100B
Protein S100-B

10

17

Small-scale

0.983

High

407583

S10A4
Protein S100-A4

6

17

High-throughput

0.952

High

407586

S10A2
Protein S100-A2

5

17

High-throughput

0.932

High

407582

S100P
Protein S100-P

4

17

High-throughput

0.909

High

407562

S10A6
Protein S100-A6

3

17

Small-scale

0.880

High

407558

P53
Cellular tumor antigen p53

4

16

Small-scale

0.874

High

407626

RAGE
Advanced glycosylation end product-specific receptor

3

9

Small-scale

0.861

High

407561

S10A9
Protein S100-A9

2

17

High-throughput

0.783

High

407671

S100Z
Protein S100-Z

2

17

High-throughput

0.783

High

407722

ASB6
Ankyrin repeat and SOCS box protein 6

2

4

High-throughput

0.776

High

407589

S10AB
Protein S100-A11

1

17

Small-scale

0.740

High

407643

RFIP1
Rab11 family-interacting protein 1

1

3

High-throughput

0.691

High

407658

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

1

High-throughput

0.691

High

407668

IASPP
RelA-associated inhibitor

1

2

High-throughput

0.691

High

407695

AGAP3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

1

1

High-throughput

0.691

High

407595

IQGA1
Ras GTPase-activating-like protein IQGAP1

3

5

Small-scale

0.675

High

407724

SPG21
Maspardin

4

0

High-throughput

0.668

High

407637

Q5T7Y6
Protein S100

1

17

High-throughput

0.665

High

407563

ANXA6
Annexin A6

1

11

Small-scale

0.647

High

407567

TAU
Microtubule-associated protein tau

3

15

Small-scale

0.646

High

407612

MDM2
E3 ubiquitin-protein ligase Mdm2

2

9

Small-scale

0.629

High

407739

LSM5
U6 snRNA-associated Sm-like protein LSm5

2

1

High-throughput

0.628

High

407603

CAZA1
F-actin-capping protein subunit alpha-1

2

4

Small-scale

0.619

High

407564

FGF2
Fibroblast growth factor 2

1

1

Small-scale

0.618

High

140109

SDCB1
Syntenin-1

2

2

High-throughput

0.606

High

407663

LNX1
E3 ubiquitin-protein ligase LNX

2

3

High-throughput

0.606

High

179659

MDM4
Protein Mdm4

2

9

Small-scale

0.602

High

407577

IL11
Interleukin-11

2

3

Small-scale

0.602

High

407588

PML
Protein PML

2

14

High-throughput

0.601

High

407611

CDK17
Cyclin-dependent kinase 17

2

11

High-throughput

0.601

High

407639

SYDE2
Rho GTPase-activating protein SYDE2

2

10

High-throughput

0.601

High

407675

ZN516
Zinc finger protein 516

2

4

High-throughput

0.601

High

407712

PEAK1
Inactive tyrosine-protein kinase PEAK1

2

11

High-throughput

0.601

High

407650

CPNE8
Copine-8

1

1

High-throughput

0.594

High

407619

AF1Q
Protein AF1q

2

0

High-throughput

0.585

High

407599

PRI1
DNA primase small subunit

2

0

High-throughput

0.576

High

407606

RL23
Large ribosomal subunit protein uL14

2

0

High-throughput

0.576

High

407609

NOP14
Nucleolar protein 14

2

0

High-throughput

0.576

High

407702

NOC4L
Nucleolar complex protein 4 homolog

2

0

High-throughput

0.576

High

407714

DCR1B
5' exonuclease Apollo

2

0

High-throughput

0.576

High

407719

DCA13
DDB1- and CUL4-associated factor 13

2

0

High-throughput

0.576

High

407573

VAV
Proto-oncogene vav

1

8

Small-scale

0.561

High

407593

PGM1
Phosphoglucomutase-1

1

1

Small-scale

0.561

High

407617

AHNK
Neuroblast differentiation-associated protein AHNAK

1

3

Small-scale

0.561

High

407627

STK38
Serine/threonine-protein kinase 38

1

9

Small-scale

0.561

High

407676

B2CL2
Bcl-2-like protein 2

1

1

High-throughput

0.560

High

407587

IMPA1
Inositol monophosphatase 1

1

1

Small-scale

0.536

High

51025

PKHG3
Pleckstrin homology domain-containing family G member 3

1

7

High-throughput

0.536

High

176384

ZBTB5
Zinc finger and BTB domain-containing protein 5

1

8

High-throughput

0.536

High

177424

ZN536
Zinc finger protein 536

1

2

High-throughput

0.536

High

219680

FOXO3
Forkhead box protein O3

1

7

High-throughput

0.536

High

219905

XRCC3
DNA repair protein XRCC3

1

2

High-throughput

0.536

High

281163

CDC45
Cell division control protein 45 homolog

1

1

High-throughput

0.536

High

289907

OFD1
Centriole and centriolar satellite protein OFD1

1

1

High-throughput

0.536

High

354200

ZBED1
E3 SUMO-protein ligase ZBED1

1

3

High-throughput

0.536

High

407571

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

1

High-throughput

0.536

High

407575

ZNF3
Zinc finger protein 3

1

4

High-throughput

0.536

High

407581

JAK1
Tyrosine-protein kinase JAK1

1

9

High-throughput

0.536

High

407585

DPOD1
DNA polymerase delta catalytic subunit

1

1

High-throughput

0.536

High

407596

NRIP1
Nuclear receptor-interacting protein 1

1

2

High-throughput

0.536

High

407598

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.536

High

407601

ERF
ETS domain-containing transcription factor ERF

1

6

High-throughput

0.536

High

407602

ZN136
Zinc finger protein 136

1

3

High-throughput

0.536

High

407604

ALR
FAD-linked sulfhydryl oxidase ALR

1

2

High-throughput

0.536

High

407610

FOXO4
Forkhead box protein O4

1

6

High-throughput

0.536

High

407614

CDK18
Cyclin-dependent kinase 18

1

11

High-throughput

0.536

High

407618

MYO1E
Unconventional myosin-Ie

1

13

High-throughput

0.536

High

407622

IQGA2
Ras GTPase-activating-like protein IQGAP2

1

5

High-throughput

0.536

High

407625

MAP7
Ensconsin

1

4

High-throughput

0.536

High

407628

MTFR1
Mitochondrial fission regulator 1

1

4

High-throughput

0.536

High

407630

TERF2
Telomeric repeat-binding factor 2

1

2

High-throughput

0.536

High

407633

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

1

High-throughput

0.536

High

407636

RHG21
Rho GTPase-activating protein 21

1

9

High-throughput

0.536

High

407640

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.536

High

407645

KDM3B
Lysine-specific demethylase 3B

1

2

High-throughput

0.536

High

407647

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

2

High-throughput

0.536

High

407648

LIPB1
Liprin-beta-1

1

16

High-throughput

0.536

High

407649

ZC3C1
Zinc finger C3HC-type protein 1

1

3

High-throughput

0.536

High

407651

ARI3B
AT-rich interactive domain-containing protein 3B

1

4

High-throughput

0.536

High

407652

MA7D3
MAP7 domain-containing protein 3

1

2

High-throughput

0.536

High

407654

TIGD4
Tigger transposable element-derived protein 4

1

2

High-throughput

0.536

High

407657

CNTRB
Centrobin

1

15

High-throughput

0.536

High

407660

CE112
Centrosomal protein of 112 kDa

1

16

High-throughput

0.536

High

407661

ZN709
Zinc finger protein 709

1

1

High-throughput

0.536

High

407662

KDM2B
Lysine-specific demethylase 2B

1

3

High-throughput

0.536

High

407665

ZN507
Zinc finger protein 507

1

3

High-throughput

0.536

High

407680

TTC28
Tetratricopeptide repeat protein 28

1

3

High-throughput

0.536

High

407683

ZBT10
Zinc finger and BTB domain-containing protein 10

1

6

High-throughput

0.536

High

407686

ZN764
Zinc finger protein 764

1

5

High-throughput

0.536

High

407687

SENP5
Sentrin-specific protease 5

1

4

High-throughput

0.536

High

407691

HIC2
Hypermethylated in cancer 2 protein

1

3

High-throughput

0.536

High

407693

ZN714
Zinc finger protein 714

1

2

High-throughput

0.536

High

407696

PUS7
Pseudouridylate synthase 7 homolog

1

2

High-throughput

0.536

High

407698

ATAD5
ATPase family AAA domain-containing protein 5

1

1

High-throughput

0.536

High

407699

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

1

High-throughput

0.536

High

407700

PIMRE
Protein PIMREG

1

1

High-throughput

0.536

High

407701

RPC7L
DNA-directed RNA polymerase III subunit RPC7-like

1

1

High-throughput

0.536

High

407704

CC106
Coiled-coil domain-containing protein 106

1

1

High-throughput

0.536

High

407705

SALL3
Sal-like protein 3

1

7

High-throughput

0.536

High

407707

TB182
182 kDa tankyrase-1-binding protein

1

3

High-throughput

0.536

High

407708

MTMRC
Myotubularin-related protein 12

1

6

High-throughput

0.536

High

407709

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.536

High

407710

TXNIP
Thioredoxin-interacting protein

1

5

High-throughput

0.536

High

407715

SENP2
Sentrin-specific protease 2

1

4

High-throughput

0.536

High

407716

RESF1
Retroelement silencing factor 1

1

1

High-throughput

0.536

High

407717

SALL1
Sal-like protein 1

1

5

High-throughput

0.536

High

407725

ZBTB4
Zinc finger and BTB domain-containing protein 4

1

3

High-throughput

0.536

High

407728

INT6
Integrator complex subunit 6

1

6

High-throughput

0.536

High

407729

ZBT21
Zinc finger and BTB domain-containing protein 21

1

3

High-throughput

0.536

High

407730

TTF2
Transcription termination factor 2

1

13

High-throughput

0.536

High

407731

PHF8
Histone lysine demethylase PHF8

1

1

High-throughput

0.536

High

407733

SCML2
Sex comb on midleg-like protein 2

1

4

High-throughput

0.536

High

407734

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

1

High-throughput

0.536

High

407736

SALL2
Sal-like protein 2

1

5

High-throughput

0.536

High

407737

ZN451
E3 SUMO-protein ligase ZNF451

1

2

High-throughput

0.536

High

407743

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

2

High-throughput

0.536

High

387354

APOE
Apolipoprotein E

1

0

High-throughput

0.518

High

156582

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

2

High-throughput

0.515

High

286339

DAB1
Disabled homolog 1

1

1

High-throughput

0.515

High

407560

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.515

High

407566

HS71A
Heat shock 70 kDa protein 1A

1

6

High-throughput

0.515

High

407574

ZNF24
Zinc finger protein 24

1

4

High-throughput

0.515

High

407576

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

4

High-throughput

0.515

High

407578

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

15

High-throughput

0.515

High

407584

CALX
Calnexin

1

1

High-throughput

0.515

High

407605

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

High-throughput

0.515

High

407607

RAC1
Ras-related C3 botulinum toxin substrate 1

1

7

High-throughput

0.515

High

407613

APLP2
Amyloid beta precursor like protein 2

1

3

High-throughput

0.515

High

407615

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

1

High-throughput

0.515

High

407624

BLMH
Bleomycin hydrolase

1

2

High-throughput

0.515

High

407738

TRAF6
TNF receptor-associated factor 6

1

20

High-throughput

0.515

High

339310

MET18
Histidine protein methyltransferase 1 homolog

1

0

High-throughput

0.513

High

407591

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.513

High

407600

PRI2
DNA primase large subunit

1

0

High-throughput

0.513

High

407616

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

0

High-throughput

0.513

High

407621

ORC2
Origin recognition complex subunit 2

1

0

High-throughput

0.513

High

407634

SGO2
Shugoshin 2

1

0

High-throughput

0.513

High

407653

SLF2
SMC5-SMC6 complex localization factor protein 2

1

0

High-throughput

0.513

High

407655

RAVR1
Ribonucleoprotein PTB-binding 1

1

0

High-throughput

0.513

High

407667

MORC4
MORC family CW-type zinc finger protein 4

1

0

High-throughput

0.513

High

407672

ELYS
Protein ELYS

1

0

High-throughput

0.513

High

407688

REXO5
RNA exonuclease 5

1

0

High-throughput

0.513

High

407697

UIF
UAP56-interacting factor

1

0

High-throughput

0.513

High

407703

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

0

High-throughput

0.513

High

407706

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.513

High

407711

PIF1
ATP-dependent DNA helicase PIF1

1

0

High-throughput

0.513

High

407723

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.513

High

407740

ORC6
Origin recognition complex subunit 6

1

0

High-throughput

0.513

High

378350

IFNB
Interferon beta

1

6

Small-scale

0.501

High

407590

NAC1
Sodium/calcium exchanger 1

1

16

Small-scale

0.501

High

407592

MYH9
Myosin-9

1

13

Small-scale

0.501

High

407629

KS6A1
Ribosomal protein S6 kinase alpha-1

1

10

Small-scale

0.501

High

407666

TRPM4
Transient receptor potential cation channel subfamily M member 4

1

12

Small-scale

0.501

High

407694

CEP20
Centrosomal protein 20

1

5

Small-scale

0.501

High

407735

FBX7
F-box only protein 7

1

2

High-throughput

0.501

High

369577

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.493

High

407570

UNG
Uracil-DNA glycosylase

1

0

High-throughput

0.493

High

407594

NBL1
Neuroblastoma suppressor of tumorigenicity 1

1

0

High-throughput

0.493

High

407597

KC1D
Casein kinase I isoform delta

1

0

High-throughput

0.493

High

407631

NEDD8
Ubiquitin-like protein NEDD8

1

0

High-throughput

0.493

High

407674

SEPT8
Septin-8

1

0

High-throughput

0.493

High

407732

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

High-throughput

0.493

High

407579

ADRO
NADPH:adrenodoxin oxidoreductase, mitochondrial

1

1

High-throughput

0.489

High

407632

CR021
UPF0711 protein C18orf21

1

4

High-throughput

0.489

High

407635

NHSL1
NHS-like protein 1

1

6

High-throughput

0.489

High

407638

ATD3B
ATPase family AAA domain-containing protein 3B

1

6

High-throughput

0.489

High

407646

UBE3B
Ubiquitin-protein ligase E3B

1

5

High-throughput

0.489

High

407656

RCOR2
REST corepressor 2

1

2

High-throughput

0.489

High

407679

C102A
Coiled-coil domain-containing protein 102A

1

15

High-throughput

0.489

High

407720

ATD3A
ATPase family AAA domain-containing protein 3A

1

6

High-throughput

0.489

High

407741

HEMK1
MTRF1L release factor glutamine methyltransferase

1

3

High-throughput

0.489

High

407678

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.486

High

407641

ATRAP
Type-1 angiotensin II receptor-associated protein

1

1

High-throughput

0.481

High

407677

MAL2
Protein MAL2

1

1

High-throughput

0.481

High

193167

SOCS1
Suppressor of cytokine signaling 1

1

4

Small-scale

0.479

High

347457

BAG3
BAG family molecular chaperone regulator 3

1

5

High-throughput

0.479

High

407568

FGFR1
Fibroblast growth factor receptor 1

1

4

Small-scale

0.479

High

407569

SRC
Proto-oncogene tyrosine-protein kinase Src

1

2

Small-scale

0.479

High

407669

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

407685

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

0

High-throughput

0.460

High

407673

NDRG1
Protein NDRG1

1

0

Small-scale

0.458

High

407608

DYL1
Dynein light chain 1, cytoplasmic

1

1

High-throughput

0.445

High

407620

CTBP1
C-terminal-binding protein 1

1

2

High-throughput

0.445

High

407623

AAMP
Angio-associated migratory cell protein

1

2

High-throughput

0.445

High

407689

GMPPA
Mannose-1-phosphate guanylyltransferase regulatory subunit alpha

1

1

High-throughput

0.445

High

407742

NCOR2
Nuclear receptor corepressor 2

1

3

High-throughput

0.445

High

407670

TM239
Transmembrane protein 239

1

1

High-throughput

0.439

High

407681

LDAF1
Lipid droplet assembly factor 1

1

1

High-throughput

0.439

High

407692

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

2

High-throughput

0.439

High

407727

PRAF1
Prenylated Rab acceptor protein 1

1

1

High-throughput

0.439

High

407559

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

407642

TBPL2
TATA box-binding protein-like 2

1

0

High-throughput

0.426

High

407721

ARGL1
Arginine and glutamate-rich protein 1

1

0

High-throughput

0.426

High

407664

RM30
Large ribosomal subunit protein uL30m

2

0

High-throughput

0.313

High

407565

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.279

Low

407572

CX6B1
Cytochrome c oxidase subunit 6B1

1

0

High-throughput

0.279

Low

407659

MET25
Probable methyltransferase-like protein 25

1

0

High-throughput

0.279

Low

407682

FWCH2
FLYWCH family member 2

1

0

High-throughput

0.279

Low

407684

HMCES
Abasic site processing protein HMCES

1

0

High-throughput

0.279

Low

407713

CPLN1
Ciliogenesis and planar polarity effector 1

1

0

High-throughput

0.279

Low

407718

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

High-throughput

0.279

Low

407726

CRCT1
Cysteine-rich C-terminal protein 1

1

0

High-throughput

0.268

Low

407644

NKAP1
Uncharacterized protein NKAPD1

1

0

High-throughput

0.265

Low

407690

ADTRP
Androgen-dependent TFPI-regulating protein

1

0

High-throughput

0.265

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025