HitPredict

Interactor 1: LRP6 (O75581)
Low-density lipoprotein receptor-related protein 6 (LRP-6)
Gene: LRP6

Interactor 2: KLK5 (Q9Y337)
Kallikrein-5 (EC 3.4.21.-) (Kallikrein-like protein 2) (KLK-L2) (Stratum corneum tryptic enzyme)
Gene: KLK5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FXa_inhibition~Trypsin, Ldl_recept_a~Trypsin
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1613 Hs			1 293
+	Hs
		270263 LRP6_HUMAN (1-1613): 0: 1791: 100.00		KLK2_HUMAN (55-292): 1.09e-99: 294: 41.20
+	Hs
		270327 LRP6_HUMAN (1-1613): 0: 1791: 100.00		KLK15_HUMAN (57-292): 1.13e-97: 289: 40.08
+	Hs
		270253 LRP6_HUMAN (1-1613): 0: 1791: 100.00		KLK3_HUMAN (58-292): 5.11e-95: 282: 40.89
+	Hs
		258362 LRP5_HUMAN (15-1613): 0: 1642: 69.70		KLK5_HUMAN (1-293): 8.79e-130: 372: 100.00
+	Hs
		258345 LRP5_HUMAN (15-1613): 0: 1642: 69.70		KLK15_HUMAN (57-292): 1.13e-97: 289: 40.08
+	Hs
		258288 LRP5_HUMAN (15-1613): 0: 1642: 69.70		KLK3_HUMAN (58-292): 5.11e-95: 282: 40.89
+	Hs
		351117 LDLR_HUMAN (1319-1612): 1.89e-23: 110: 8.70		KLK5_HUMAN (1-293): 8.79e-130: 372: 100.00
+	Hs
		351119 LDLR_HUMAN (1319-1612): 1.89e-23: 110: 8.70		ST14_HUMAN (27-288): 1.3e-94: 299: 32.50
+	Hs
		351104 LDLR_HUMAN (1319-1612): 1.89e-23: 110: 8.70		KLK15_HUMAN (57-292): 1.13e-97: 289: 40.08
+	Hs
		957531 VLDLR_HUMAN (1167-1395): 1.74e-17: 90.9: 22.69		ST14_HUMAN (27-288): 1.3e-94: 299: 32.50
+	Hs
		409510 VLDLR_HUMAN (1167-1395): 1.74e-17: 90.9: 22.69		HEPS_HUMAN (35-293): 6.87e-94: 285: 30.99
+	Hs
		371465 NID2_HUMAN (542-627): 4.1e-10: 67: 21.59		KLKB1_HUMAN (57-292): 5.33e-92: 287: 33.07