HitPredict

Interactor 1: CREST (O75177)
Calcium-responsive transactivator (SS18-like protein 1) (SYT homolog 1)
Gene: SS18L1

Interactor 2: ATF3 (P18847)
Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3)
Gene: ATF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 396 Hs			1 181
+	Hs
		273965 CREST_HUMAN (1-396): 3.17e-78: 248: 100.00		FOS_HUMAN (14-175): 3.48e-21: 90.6: 20.34
+	Mm
		599653 SSXT_MOUSE (1-396): 7.29e-71: 230: 56.22		ATF2_MOUSE (17-168): 1.7e-22: 95.3: 21.05
+	Hs
		583556 SSXT_HUMAN (1-396): 5.48e-68: 222: 53.83		ATF2_HUMAN (17-168): 1.46e-23: 98.4: 21.05
+	Hs
		429944 SSXT_HUMAN (1-396): 5.48e-68: 222: 53.83		JUN_HUMAN (4-160): 3.3e-22: 93: 18.52
+	Hs
		370677 SSXT_HUMAN (1-396): 5.48e-68: 222: 53.83		FOS_HUMAN (14-175): 3.48e-21: 90.6: 20.34
+	Hs
		62703 A4PIW0_HUMAN (1-342): 3.8e-54: 187: 47.65		ATF2_HUMAN (17-168): 1.46e-23: 98.4: 21.05
+	Hs
		62698 A4PIV8_HUMAN (1-381): 2.64e-52: 182: 43.75		ATF2_HUMAN (17-168): 1.46e-23: 98.4: 21.05
+	Mm
		432092 SMCA2_MOUSE (74-384): 6.61e-36: 142: 17.93		JUN_MOUSE (4-160): 1.5e-21: 91: 19.39
+	Mm
		370855 SMCA2_MOUSE (74-384): 6.61e-36: 142: 17.93		FOS_MOUSE (13-175): 2.06e-20: 88.7: 25.43
+	Hs
		429550 SMCA2_HUMAN (74-384): 1.05e-26: 114: 15.67		JUN_HUMAN (4-160): 3.3e-22: 93: 18.52
+	Hs
		370603 SMCA2_HUMAN (74-384): 1.05e-26: 114: 15.67		FOS_HUMAN (14-175): 3.48e-21: 90.6: 20.34
+	Hs
		606453 SMCA2_HUMAN (74-384): 1.05e-26: 114: 15.67		CEBPB_HUMAN (55-148): 2.81e-20: 88: 23.40
+	Hs
		617137 SMCA4_HUMAN (74-338): 1.2e-10: 65.5: 11.08		ATF3_HUMAN (1-181): 2.88e-40: 136: 100.00
+	Hs
		429551 SMCA4_HUMAN (74-338): 1.2e-10: 65.5: 11.08		JUN_HUMAN (4-160): 3.3e-22: 93: 18.52
+	Hs
		370604 SMCA4_HUMAN (74-338): 1.2e-10: 65.5: 11.08		FOS_HUMAN (14-175): 3.48e-21: 90.6: 20.34
+	Hs
		603629 SMCA4_HUMAN (74-338): 1.2e-10: 65.5: 11.08		JUNB_HUMAN (31-156): 4.24e-21: 90.3: 19.85
+	Hs
		429576 SC24C_HUMAN (134-389): 2.68e-09: 61.2: 15.97		JUN_HUMAN (4-160): 3.3e-22: 93: 18.52
+	Hs
		606454 SMCA4_HUMAN (74-338): 1.2e-10: 65.5: 11.08		CEBPB_HUMAN (55-148): 2.81e-20: 88: 23.40
+	Hs
		606490 SC24C_HUMAN (134-389): 2.68e-09: 61.2: 15.97		CEBPB_HUMAN (55-148): 2.81e-20: 88: 23.40
+	Hs
		607175 CHD7_HUMAN (39-357): 2.99e-09: 61.2: 11.83		CEBPB_HUMAN (55-148): 2.81e-20: 88: 23.40