HitPredict

Interactor 1: PIAS2 (O75928)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Interactor 2: SMAD4 (Q13485)
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
Gene: SMAD4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	16777850
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006351 - DNA-templated transcription GO:0006357 - regulation of transcription by RNA polymerase II GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 621 Hs			1 552
+	Hs
		1035653 PIAS3_HUMAN (1-621): 0: 666: 55.25		SMAD4_HUMAN (1-552): 0: 696: 100.00
+	Hs
		278075 PIAS1_HUMAN (1-621): 0: 653: 54.10		SMAD4_HUMAN (1-552): 0: 696: 100.00
+	Hs
		278264 PIAS2_HUMAN (1-621): 0: 811: 100.00		SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22
+	Hs
		1035500 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		SMAD4_HUMAN (1-552): 0: 696: 100.00
+	Hs
		278098 PIAS1_HUMAN (1-621): 0: 653: 54.10		SMAD1_HUMAN (20-546): 0: 542: 34.91
+	Hs
		950349 PIAS3_HUMAN (1-621): 0: 666: 55.25		SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22
+	Hs
		1078712 PIAS3_HUMAN (1-621): 0: 666: 55.25		SMAD2_HUMAN (19-549): 1.81e-166: 482: 28.65
+	Hs
		1078729 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		SMAD1_HUMAN (20-546): 0: 542: 34.91
+	Hs
		950220 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22
+	Hs
		1078585 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		SMAD2_HUMAN (19-549): 1.81e-166: 482: 28.65
+	Hs
		1035630 ZMIZ1_HUMAN (65-460): 1.71e-75: 262: 23.04		SMAD4_HUMAN (1-552): 0: 696: 100.00
+	Hs
		206981 PIAS3_HUMAN (1-621): 0: 666: 55.25		SMAD6_HUMAN (33-205): 9.59e-32: 130: 28.98
+	Hs
		950322 ZMIZ1_HUMAN (65-460): 1.71e-75: 262: 23.04		SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22
+	Hs
		167316 PIAS1_HUMAN (1-621): 0: 653: 54.10		SMAD7_HUMAN (33-137): 4.06e-26: 112: 28.45
+	Hs
		206968 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		SMAD6_HUMAN (33-205): 9.59e-32: 130: 28.98
+	Hs
		167374 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		SMAD7_HUMAN (33-137): 4.06e-26: 112: 28.45