HitPredict

Interactor 1: PIAS2 (O75928)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Interactor 2: SIAH1 (Q8IUQ4)
E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a)
Gene: SIAH1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	17533377
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0008270 - zinc ion binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 621 Hs			1 282
+	Hs
		199075 PIAS2_HUMAN (1-621): 0: 811: 100.00		SIAH2_HUMAN (28-282): 1.74e-103: 306: 83.20
+	Hs
		1216744 PIAS3_HUMAN (1-621): 0: 666: 55.25		SIAH1_HUMAN (1-282): 7.29e-121: 348: 100.00
+	Hs
		278124 PIAS1_HUMAN (1-621): 0: 653: 54.10		SIAH1_HUMAN (1-282): 7.29e-121: 348: 100.00
+	Hs
		278302 PIAS2_HUMAN (1-621): 0: 811: 100.00		TRI50_HUMAN (34-235): 9.68e-46: 162: 19.15
+	Hs
		199158 PIAS3_HUMAN (1-621): 0: 666: 55.25		SIAH2_HUMAN (28-282): 1.74e-103: 306: 83.20
+	Hs
		199074 PIAS1_HUMAN (1-621): 0: 653: 54.10		SIAH2_HUMAN (28-282): 1.74e-103: 306: 83.20
+	Hs
		129520 PIAS2_HUMAN (1-621): 0: 811: 100.00		TRAF5_HUMAN (25-148): 2.59e-26: 109: 19.55
+	Hs
		278274 PIAS2_HUMAN (1-621): 0: 811: 100.00		TRAF3_HUMAN (1-150): 1.22e-25: 107: 15.79