HitPredict

Interactor 1: KT33A (O76009)
Keratin, type I cuticular Ha3-I (Hair keratin, type I Ha3-I) (Keratin-33A) (K33A)
Gene: KRT33A

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	19380743
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 404 Hs			1 217
+	Hs
		359329 K1C14_HUMAN (54-367): 2.36e-143: 417: 61.15		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		444346 K1C19_HUMAN (49-366): 5.76e-142: 411: 56.29		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924493 K1C17_HUMAN (49-367): 1.13e-112: 338: 59.88		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		445027 K1C16_HUMAN (54-369): 2.3e-111: 336: 60.44		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		580010 K1C15_HUMAN (55-367): 4.12e-108: 327: 57.96		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924679 K2C73_HUMAN (9-404): 1.04e-93: 293: 23.87		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		531343 K1C10_HUMAN (52-361): 8.5e-92: 289: 56.01		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924469 KRT83_HUMAN (2-403): 1.83e-92: 288: 26.24		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924576 KRT81_HUMAN (2-403): 2.78e-92: 288: 26.73		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924470 KRT85_HUMAN (2-403): 2e-90: 283: 26.80		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		213936 KRT86_HUMAN (2-401): 3.99e-90: 282: 26.43		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		280559 KRT34_HUMAN (1-391): 2.51e-90: 279: 90.03		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924895 KRT82_HUMAN (1-401): 7.36e-86: 271: 24.88		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		442846 K1C40_HUMAN (2-387): 1.93e-145: 421: 61.71		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		275168 K1C13_HUMAN (45-380): 1.34e-140: 410: 53.71		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62
+	Mm
		403444 K1C14_MOUSE (55-367): 8.24e-110: 332: 59.43		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Mm
		403471 K1C16_MOUSE (55-364): 1.04e-105: 321: 59.03		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		522739 K1C10_HUMAN (52-361): 8.5e-92: 289: 56.01		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		280510 KRT34_HUMAN (1-391): 2.51e-90: 279: 90.03		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Mm
		403456 K2C5_MOUSE (19-381): 2.2e-89: 283: 25.48		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58