HitPredict

Interactor 1: KRT34 (O76011)
Keratin, type I cuticular Ha4 (Hair keratin, type I Ha4) (Keratin-34) (K34)
Gene: KRT34

Interactor 2: K2C1B (Q7Z794)
Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39)
Gene: KRT77

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	36949045
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0045109 - intermediate filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 394 Hs			1 578
+	Hs
		380631 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C1_HUMAN (129-510): 2.95e-163: 481: 68.06
+	Hs
		517761 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C3_HUMAN (136-480): 1.68e-149: 446: 68.01
+	Hs
		409116 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C8_HUMAN (136-521): 2.3e-135: 404: 55.70
+	Hs
		1149217 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C78_HUMAN (88-523): 1e-117: 360: 50.89
+	Hs
		1149205 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C73_HUMAN (1-572): 7.47e-95: 302: 51.75
+	Hs
		318825 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C75_HUMAN (1-566): 2.11e-93: 298: 53.95
+	Hs
		943639 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		KRT83_HUMAN (43-485): 6.44e-90: 287: 43.02
+	Hs
		1055208 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		KRT81_HUMAN (50-479): 1.09e-88: 284: 43.85
+	Hs
		213959 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		KRT86_HUMAN (45-485): 6.72e-88: 282: 43.44
+	Hs
		943678 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		KRT85_HUMAN (39-485): 6.33e-88: 282: 43.11
+	Hs
		1140432 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C79_HUMAN (3-554): 1.21e-86: 280: 52.16
+	Hs
		531587 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C5_HUMAN (1-480): 3.81e-83: 272: 58.23
+	Hs
		380488 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C6B_HUMAN (3-496): 3.98e-82: 269: 58.38
+	Hs
		821668 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C6C_HUMAN (3-496): 7.26e-82: 269: 57.78
+	Hs
		1110335 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C71_HUMAN (1-557): 2.89e-82: 268: 49.91
+	Hs
		359503 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C6A_HUMAN (3-496): 5.58e-78: 258: 58.38
+	Hs
		1062054 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C72_HUMAN (1-561): 2.4e-77: 255: 48.31
+	Hs
		1149190 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C74_HUMAN (1-550): 2.96e-74: 247: 50.00
+	Hs
		580138 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K2C4_HUMAN (5-496): 3.75e-73: 244: 57.52
+	Hs
		965435 K1C40_HUMAN (4-387): 5.61e-144: 417: 63.68		K22O_HUMAN (1-492): 1.25e-67: 232: 54.86