HitPredict

Interactor 1: WFS1 (O76024)
Wolframin
Gene: WFS1

Interactor 2: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.50	0.583

Property	Details
Experiments	21454619, 32814053
Identification Methods	two hybrid, affinity chromatography technology, pull down, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 890 Hs			1 757
+	Mm
		881842 WFS1_MOUSE (24-890): 0: 1668: 86.90		SMUF1_MOUSE (1-757): 0: 855: 95.24
+	Hs
		125056 WFS1_HUMAN (1-890): 0: 1786: 100.00		WWP2_HUMAN (97-757): 0: 708: 36.69