Protein: PHB2
Prohibitin-2

Gene: PHB2
Organism: Saccharomyces cerevisiae S288C
Interactions: 104
UniProt ID: P50085

Gene Ontology (top 5):
GO:0000001 - mitochondrion inheritance
GO:0000423 - mitophagy
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006457 - protein folding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

829840

PHB1
Prohibitin-1

6

14

Small-scale

0.946

High

814947

AFG3
Mitochondrial inner membrane m-AAA protease component YTA10

3

10

Small-scale

0.847

High

823076

YTA12
Mitochondrial inner membrane m-AAA protease component YTA12

2

14

High-throughput

0.789

High

893042

PHB2
Prohibitin-2

1

14

High-throughput

0.618

High

417142

VDAC1
Non-selective voltage-gated ion channel 1

2

9

High-throughput

0.584

High

781417

MIC60
MICOS complex subunit MIC60

2

1

High-throughput

0.584

High

815696

OXA1
Mitochondrial inner membrane protein OXA1

2

2

High-throughput

0.584

High

881390

TOM22
Mitochondrial import receptor subunit TOM22

2

1

High-throughput

0.584

High

545514

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.521

High

801078

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.513

High

656540

KC11
Casein kinase I homolog 1

1

2

High-throughput

0.501

High

564751

ATC1
Calcium-transporting ATPase 1

1

7

High-throughput

0.489

High

744063

ANP1
Mannan polymerase II complex ANP1 subunit

1

3

High-throughput

0.489

High

757632

SIP2
SNF1 protein kinase subunit beta-2

1

1

High-throughput

0.489

High

811571

MNN9
Mannan polymerase complexes subunit MNN9

1

3

High-throughput

0.489

High

816593

GEA2
ARF guanine-nucleotide exchange factor 2

1

2

High-throughput

0.489

High

863611

MNN11
Probable alpha-1,6-mannosyltransferase MNN11

1

1

High-throughput

0.489

High

357776

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

1

High-throughput

0.479

High

357839

QCR7
Cytochrome b-c1 complex subunit 7, mitochondrial

1

1

High-throughput

0.479

High

360673

COX2
Cytochrome c oxidase subunit 2

1

4

High-throughput

0.479

High

360800

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

3

High-throughput

0.479

High

360835

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

3

High-throughput

0.479

High

360893

COX6
Cytochrome c oxidase subunit 6, mitochondrial

1

1

High-throughput

0.479

High

382948

RMAR
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.479

High

399860

COX4
Cytochrome c oxidase subunit 4, mitochondrial

1

1

High-throughput

0.479

High

453179

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

10

High-throughput

0.479

High

453293

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

10

High-throughput

0.479

High

465347

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

1

High-throughput

0.479

High

470693

QCR8
Cytochrome b-c1 complex subunit 8, mitochondrial

1

1

High-throughput

0.479

High

510644

HSP77
Import motor subunit, mitochondrial

1

8

High-throughput

0.479

High

661807

TOM40
Mitochondrial import receptor subunit TOM40

1

1

High-throughput

0.479

High

670914

SIS1
Protein SIS1

1

3

High-throughput

0.479

High

736280

RM41
Large ribosomal subunit protein uL23m

1

1

High-throughput

0.479

High

745243

COX13
Cytochrome c oxidase subunit 13, mitochondrial

1

1

High-throughput

0.479

High

746586

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

2

High-throughput

0.479

High

746885

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

2

High-throughput

0.479

High

752491

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.479

High

785944

LONM
Lon protease homolog, mitochondrial

1

8

Small-scale

0.479

High

795452

ATG8
Autophagy-related protein 8

1

8

Small-scale

0.479

High

798479

MIC12
MICOS complex subunit MIC12

1

1

Small-scale

0.479

High

803474

TCD1
tRNA threonylcarbamoyladenosine dehydratase 1

1

1

High-throughput

0.479

High

804816

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

2

High-throughput

0.479

High

818622

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

1

High-throughput

0.479

High

893045

MCY1
Putative mitochondrial cysteine synthase

1

2

High-throughput

0.479

High

893046

RCF2
Respiratory supercomplex factor 2, mitochondrial

1

1

High-throughput

0.479

High

893048

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

893051

COX12
Cytochrome c oxidase subunit 12, mitochondrial

1

2

High-throughput

0.479

High

893055

VMS1
tRNA endonuclease VMS1

1

1

High-throughput

0.479

High

893056

ATG33
Autophagy-related protein 33

1

1

High-throughput

0.479

High

893060

YD157
Uncharacterized protein YDL157C, mitochondrial

1

1

Small-scale

0.479

High

893063

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

1

High-throughput

0.479

High

893064

MIC10
MICOS complex subunit MIC10

1

1

Small-scale

0.479

High

613775

MDM10
Mitochondrial distribution and morphology protein 10

1

0

High-throughput

0.458

High

798102

OM14
Mitochondrial outer membrane protein OM14

1

0

Small-scale

0.458

High

825642

PUP1
PUP1 protein homolog

1

0

High-throughput

0.458

High

893047

ATP23
Mitochondrial inner membrane protease ATP23

1

0

High-throughput

0.458

High

893054

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

673714

KCC4
Probable serine/threonine-protein kinase KCC4

1

3

High-throughput

0.457

High

778911

NNK1
Nitrogen network kinase 1

1

2

High-throughput

0.457

High

394712

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

453681

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.445

High

470557

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.445

High

527139

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

626808

HSP60
Heat shock protein 60, mitochondrial

1

4

High-throughput

0.445

High

755132

GCN1
eIF-2-alpha kinase activator GCN1

1

8

High-throughput

0.445

High

779426

MAOM
NAD-dependent malic enzyme, mitochondrial

1

1

High-throughput

0.445

High

796996

PHO88
SRP-independent targeting protein 3

1

1

High-throughput

0.445

High

893053

CLU
Clustered mitochondria protein 1

1

1

High-throughput

0.445

High

893059

MDN1
Midasin

1

7

High-throughput

0.445

High

893061

HSP42
Heat shock protein 42

1

2

High-throughput

0.445

High

893062

RUVB2
RuvB-like protein 2

1

4

High-throughput

0.445

High

558804

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

705200

PEX3
Peroxisomal biogenesis factor 3

1

1

High-throughput

0.437

High

707609

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

795094

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

819230

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.437

High

824917

TM108
Protein TMA108

1

4

High-throughput

0.437

High

864776

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.437

High

893044

PEX14
Peroxisomal membrane protein PEX14

1

2

Small-scale

0.437

High

893052

TOM1
E3 ubiquitin-protein ligase TOM1

1

7

High-throughput

0.437

High

893057

SGO1
Shugoshin

1

1

High-throughput

0.437

High

893058

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.437

High

382212

H4
Histone H4

1

2

High-throughput

0.407

High

386780

TBB
Tubulin beta chain

1

9

High-throughput

0.407

High

427354

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.407

High

486249

TBA1
Tubulin alpha-1 chain

1

6

High-throughput

0.407

High

518333

IF4A
ATP-dependent RNA helicase eIF4A

1

5

High-throughput

0.407

High

592360

VATB
V-type proton ATPase subunit B

1

5

High-throughput

0.407

High

734150

EF2
Elongation factor 2

1

4

High-throughput

0.407

High

747470

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.407

High

753469

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.407

High

796101

IMB2
Importin subunit beta-2

1

8

High-throughput

0.407

High

802658

YHI0
Putative proline--tRNA ligase YHR020W

1

2

High-throughput

0.407

High

803150

ECM29
Proteasome component ECM29

1

9

High-throughput

0.407

High

803615

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.407

High

836059

COPB2
Coatomer subunit beta'

1

6

High-throughput

0.407

High

858026

RSSA2
Small ribosomal subunit protein uS2B

1

3

High-throughput

0.407

High

893049

SNA2
Protein SNA2

1

1

High-throughput

0.407

High

893050

ACT
Actin

1

5

High-throughput

0.407

High

744502

KA122
Importin beta-like protein KAP122

1

0

High-throughput

0.279

Low

757769

SAS3
Histone acetyltransferase SAS3

1

0

Small-scale

0.279

Low

813598

ERP2
Protein ERP2

1

0

High-throughput

0.269

Low

893043

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025