Protein: PHB1
Prohibitin-1

Gene: PHB1
Organism: Saccharomyces cerevisiae S288C
Interactions: 92
UniProt ID: P40961

Gene Ontology (top 5):
GO:0000001 - mitochondrion inheritance
GO:0000423 - mitophagy
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006457 - protein folding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

829840

PHB2
Prohibitin-2

6

14

Small-scale

0.946

High

814944

AFG3
Mitochondrial inner membrane m-AAA protease component YTA10

5

10

Small-scale

0.915

High

823074

YTA12
Mitochondrial inner membrane m-AAA protease component YTA12

3

14

Small-scale

0.847

High

781402

MIC60
MICOS complex subunit MIC60

3

1

High-throughput

0.640

High

360665

COX2
Cytochrome c oxidase subunit 2

2

4

Small-scale

0.584

High

417124

VDAC1
Non-selective voltage-gated ion channel 1

2

9

Small-scale

0.584

High

752368

HSP78
Heat shock protein 78, mitochondrial

2

3

High-throughput

0.584

High

795403

ATG8
Autophagy-related protein 8

2

8

Small-scale

0.584

High

829839

TOM22
Mitochondrial import receptor subunit TOM22

2

1

High-throughput

0.584

High

829850

ERP1
Protein ERP1

2

0

High-throughput

0.563

High

564741

ATC1
Calcium-transporting ATPase 1

1

7

High-throughput

0.489

High

744056

ANP1
Mannan polymerase II complex ANP1 subunit

1

3

High-throughput

0.489

High

811564

MNN9
Mannan polymerase complexes subunit MNN9

1

3

High-throughput

0.489

High

829836

MNN11
Probable alpha-1,6-mannosyltransferase MNN11

1

1

High-throughput

0.489

High

357774

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

1

High-throughput

0.479

High

357836

QCR7
Cytochrome b-c1 complex subunit 7, mitochondrial

1

1

High-throughput

0.479

High

360797

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

3

High-throughput

0.479

High

360833

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

3

High-throughput

0.479

High

360887

COX6
Cytochrome c oxidase subunit 6, mitochondrial

1

1

High-throughput

0.479

High

382930

RMAR
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.479

High

399850

COX4
Cytochrome c oxidase subunit 4, mitochondrial

1

1

High-throughput

0.479

High

453167

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

10

High-throughput

0.479

High

453285

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

10

High-throughput

0.479

High

465341

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

1

High-throughput

0.479

High

470689

QCR8
Cytochrome b-c1 complex subunit 8, mitochondrial

1

1

High-throughput

0.479

High

482202

ATPO
ATP synthase subunit 5, mitochondrial

1

4

High-throughput

0.479

High

510568

HSP77
Import motor subunit, mitochondrial

1

8

High-throughput

0.479

High

618951

IRA2
Inhibitory regulator protein IRA2

1

3

Small-scale

0.479

High

661804

TOM40
Mitochondrial import receptor subunit TOM40

1

1

High-throughput

0.479

High

670816

SIS1
Protein SIS1

1

3

High-throughput

0.479

High

736272

RM41
Large ribosomal subunit protein uL23m

1

1

High-throughput

0.479

High

745239

COX13
Cytochrome c oxidase subunit 13, mitochondrial

1

1

High-throughput

0.479

High

746582

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

2

High-throughput

0.479

High

746866

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

2

High-throughput

0.479

High

748750

YPT7
Ypt/Rab-type GTPase YPT7

1

8

Small-scale

0.479

High

785934

LONM
Lon protease homolog, mitochondrial

1

8

Small-scale

0.479

High

798476

MIC12
MICOS complex subunit MIC12

1

1

Small-scale

0.479

High

803472

TCD1
tRNA threonylcarbamoyladenosine dehydratase 1

1

1

High-throughput

0.479

High

804808

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

2

High-throughput

0.479

High

818613

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

1

High-throughput

0.479

High

829842

MCY1
Putative mitochondrial cysteine synthase

1

2

High-throughput

0.479

High

829844

RCF2
Respiratory supercomplex factor 2, mitochondrial

1

1

High-throughput

0.479

High

829846

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

829848

COX12
Cytochrome c oxidase subunit 12, mitochondrial

1

2

High-throughput

0.479

High

829849

VMS1
tRNA endonuclease VMS1

1

1

High-throughput

0.479

High

829851

ATG33
Autophagy-related protein 33

1

1

High-throughput

0.479

High

829859

FSF1
Sideroflexin FSF1

1

4

High-throughput

0.479

High

829860

YD157
Uncharacterized protein YDL157C, mitochondrial

1

1

Small-scale

0.479

High

829861

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

1

High-throughput

0.479

High

829862

MIC10
MICOS complex subunit MIC10

1

1

Small-scale

0.479

High

432013

ATPF
ATP synthase subunit 4, mitochondrial

1

0

High-throughput

0.458

High

677079

MGR1
Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR1

1

0

High-throughput

0.458

High

784322

RM17
Large ribosomal subunit protein mL46

1

0

High-throughput

0.458

High

790393

QCR10
Cytochrome b-c1 complex subunit 10, mitochondrial

1

0

High-throughput

0.458

High

453645

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.445

High

524230

HSP71
Heat shock protein SSA1

1

5

High-throughput

0.445

High

526924

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

796955

PHO88
SRP-independent targeting protein 3

1

1

High-throughput

0.445

High

805484

TOM71
Protein TOM71

1

4

High-throughput

0.445

High

815687

OXA1
Mitochondrial inner membrane protein OXA1

1

2

High-throughput

0.445

High

376193

RAS1
Ras-like protein 1

1

11

High-throughput

0.437

High

441960

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

445346

CDC31
Cell division control protein 31

1

1

Small-scale

0.437

High

512488

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.437

High

513057

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

515116

RL19B
Large ribosomal subunit protein eL19

1

1

High-throughput

0.437

High

558763

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

674673

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.437

High

705189

PEX3
Peroxisomal biogenesis factor 3

1

1

High-throughput

0.437

High

707351

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

727103

HS104
Heat shock protein 104

1

5

Small-scale

0.437

High

747417

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.437

High

795042

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

824898

TM108
Protein TMA108

1

4

High-throughput

0.437

High

829837

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.437

High

829841

PEX14
Peroxisomal membrane protein PEX14

1

2

Small-scale

0.437

High

829843

COPA
Coatomer subunit alpha

1

6

High-throughput

0.437

High

829845

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.437

High

829854

SGO1
Shugoshin

1

1

High-throughput

0.437

High

829855

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.437

High

829856

NCBP2
Nuclear cap-binding protein subunit 2

1

10

High-throughput

0.437

High

829858

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.437

High

386744

TBB
Tubulin beta chain

1

9

High-throughput

0.407

High

486215

TBA1
Tubulin alpha-1 chain

1

6

High-throughput

0.407

High

818989

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.407

High

829835

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

829847

SNA2
Protein SNA2

1

1

High-throughput

0.407

High

829857

KEL3
Kelch repeat-containing protein 3

1

0

High-throughput

0.282

High

797748

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.249

Low

829838

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

829852

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

829853

GPN3
GPN-loop GTPase 3

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025