HitPredict

Interactor 1: RNF8 (O76064)
E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8)
Gene: RNF8

Interactor 2: UBE2W (Q96B02)
Ubiquitin-conjugating enzyme E2 W (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme W) (N-terminal E2 ubiquitin-conjugating enzyme) (EC 2.3.2.25) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W)
Gene: UBE2W

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 485 Hs			1 151
+	Hs
		282581 RNF8_HUMAN (1-485): 0: 523: 100.00		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		282607 RNF8_HUMAN (1-485): 0: 523: 100.00		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		282595 RNF8_HUMAN (1-485): 0: 523: 100.00		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		282716 RNF8_HUMAN (1-485): 0: 523: 100.00		UB2E2_HUMAN (1-150): 3.17e-66: 201: 34.67
+	Hs
		282705 RNF8_HUMAN (1-485): 0: 523: 100.00		UB2E3_HUMAN (1-150): 1.13e-65: 200: 35.33
+	Hs
		282582 RNF8_HUMAN (1-485): 0: 523: 100.00		UB2E1_HUMAN (1-150): 3.64e-64: 196: 34.00
+	Hs
		1290127 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37
+	Hs
		849404 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		919820 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		895874 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		1290120 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2E2_HUMAN (1-150): 3.17e-66: 201: 34.67
+	Hs
		1282325 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2E3_HUMAN (1-150): 1.13e-65: 200: 35.33
+	Hs
		851866 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2E1_HUMAN (1-150): 3.64e-64: 196: 34.00
+	Hs
		1284870 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UBE2W_HUMAN (1-151): 1.05e-62: 190: 100.00
+	Hs
		849415 UHRF2_HUMAN (204-472): 7.12e-40: 155: 13.07		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		919833 UHRF2_HUMAN (204-472): 7.12e-40: 155: 13.07		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		895886 UHRF2_HUMAN (204-472): 7.12e-40: 155: 13.07		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	At
		639387 BRE1B_ARATH (137-446): 1.13e-41: 160: 17.74		UBC1_ARATH (1-148): 6.59e-64: 193: 31.54
+	At
		790157 BRE1B_ARATH (137-446): 1.13e-41: 160: 17.74		UBC2_ARATH (1-148): 1.76e-63: 193: 30.87
+	Hs
		1284876 UHRF2_HUMAN (204-472): 7.12e-40: 155: 13.07		UBE2W_HUMAN (1-151): 1.05e-62: 190: 100.00