HitPredict

Interactor 1: U520 (O75643)
U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD)
Gene: SNRNP200

Interactor 2: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.635

Property	Details
Experiments	35271311, 15848144
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 2136 Hs			1 765
+	Hs
		289579 U520_HUMAN (1-2136): 0: 1857: 100.00		NIPBL_HUMAN (2-213): 5.36e-35: 146: 14.29
+	Hs
		542104 DDX42_HUMAN (233-900): 4.1e-104: 360: 13.46		TOP1_HUMAN (1-765): 0: 952: 100.00
+	Hs
		541875 MTREX_HUMAN (1287-2037): 2.51e-101: 354: 18.12		TOP1_HUMAN (1-765): 0: 952: 100.00
+	Hs
		542145 DDX17_HUMAN (402-901): 4.61e-104: 353: 13.64		TOP1_HUMAN (1-765): 0: 952: 100.00
+	Hs
		541815 DDX5_HUMAN (375-901): 9.18e-103: 346: 12.83		TOP1_HUMAN (1-765): 0: 952: 100.00
+	Hs
		542191 DDX23_HUMAN (1241-1748): 4.26e-87: 306: 14.36		TOP1_HUMAN (1-765): 0: 952: 100.00
+	Hs
		238857 DHX16_HUMAN (1094-2008): 7.29e-66: 246: 11.01		TOP1_HUMAN (1-765): 0: 952: 100.00
+	Hs
		1235665 DDX17_HUMAN (402-901): 4.61e-104: 353: 13.64		NIPBL_HUMAN (2-213): 5.36e-35: 146: 14.29