HitPredict

Interactor 1: MTA2 (O94776)
Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex)
Gene: MTA2

Interactor 2: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	21670149, 23708667, 27728808
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BAH~BAH, BAH~DNA_methylase
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 668 Hs			1 1616
+	Hs
		641209 MTA1_HUMAN (1-668): 0: 704: 56.24		DNMT1_HUMAN (1-1616): 0: 1717: 100.00
+	Hs
		296161 MTA2_HUMAN (1-668): 0: 776: 100.00		DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65
+	Hs
		1031966 MTA1_HUMAN (1-668): 0: 704: 56.24		DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65