Protein: NALP2
NACHT, LRR and PYD domains-containing protein 2 (Nucleotide-binding site protein 1) (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2)

Gene: NALP2, NLRP2
Organism: Homo sapiens
Interactions: 53
UniProt ID: Q9NX02

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0006915 - apoptotic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1451613

ASC
Apoptosis-associated speck-like protein containing a CARD

2

18

Small-scale

0.776

High

947395

NALP5
NACHT, LRR and PYD domains-containing protein 5

1

17

High-throughput

0.691

High

1201303

PYDC2
Pyrin domain-containing protein 2

1

16

Small-scale

0.683

High

167980

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

14

Small-scale

0.665

High

177952

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

14

Small-scale

0.665

High

194792

MEFV
Pyrin

1

13

Small-scale

0.618

High

891826

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.618

High

1360126

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

18

Small-scale

0.618

High

1451617

SGT1
Protein SGT1 homolog

2

13

Small-scale

0.612

High

261884

PFD1
Prefoldin subunit 1

2

1

High-throughput

0.601

High

892954

MRE11
Double-strand break repair protein MRE11

2

0

Small-scale

0.559

High

158510

RFXK
DNA-binding protein RFXANK

1

4

High-throughput

0.536

High

163599

TPP1
Tripeptidyl-peptidase 1

1

1

High-throughput

0.536

High

295645

CIB2
Calcium and integrin-binding family member 2

1

3

High-throughput

0.536

High

334256

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

1

High-throughput

0.536

High

636898

GSTM3
Glutathione S-transferase Mu 3

1

3

High-throughput

0.536

High

1329904

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.536

High

1383875

EFMT3
EEF1A lysine methyltransferase 3

1

2

High-throughput

0.536

High

1434759

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.536

High

1447995

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.536

High

1451612

CRIPT
Cysteine-rich PDZ-binding protein

1

1

High-throughput

0.536

High

1451618

NEMO
NF-kappa-B essential modulator

1

4

Small-scale

0.515

High

168458

NCTR3
Natural cytotoxicity triggering receptor 3

1

0

High-throughput

0.513

High

359882

DYR
Dihydrofolate reductase

1

0

High-throughput

0.513

High

366445

FA12
Coagulation factor XII

1

0

High-throughput

0.513

High

1410704

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

0

High-throughput

0.513

High

1420238

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1439284

E41L5
Band 4.1-like protein 5

1

0

High-throughput

0.513

High

1451616

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.513

High

1451614

FAF1
FAS-associated factor 1

1

6

Small-scale

0.508

High

1227568

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.500

High

690056

CRBB3
Beta-crystallin B3

1

1

High-throughput

0.489

High

1146531

TTF1
Transcription termination factor 1

1

1

High-throughput

0.489

High

1428608

DNAI2
Dynein axonemal intermediate chain 2

1

2

High-throughput

0.489

High

1451615

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

2

High-throughput

0.489

High

423314

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

461980

HS90A
Heat shock protein HSP 90-alpha

1

12

Small-scale

0.479

High

487817

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

556376

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

712895

CASP1
Caspase-1

1

20

Small-scale

0.479

High

1122958

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

6

Small-scale

0.479

High

1126771

BECN1
Beclin-1

1

6

High-throughput

0.479

High

1141975

EEA1
Early endosome antigen 1

1

6

High-throughput

0.479

High

1279914

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

2

High-throughput

0.479

High

1369785

RAD50
DNA repair protein RAD50

1

7

Small-scale

0.479

High

303350

PDE9A
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

1

0

High-throughput

0.458

High

1106721

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

591861

H2AX
Histone H2AX

1

4

Small-scale

0.437

High

116349

H3BSK8
RB binding protein 6, ubiquitin ligase

1

1

High-throughput

0.407

High

117317

K7ER46
Beclin 1

1

6

High-throughput

0.407

High

1253668

PKHG7
Pleckstrin homology domain-containing family G member 7

1

1

High-throughput

0.407

High

1149816

TAF13
Transcription initiation factor TFIID subunit 13

1

0

High-throughput

0.279

Low

1407001

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025