HitPredict

Interactor 1: A0A0D9SGF6 (A0A0D9SGF6)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain)
Gene: SPTAN1

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned1853
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	EF-hand_7~Pkinase
Common GO terms	GO:0003779 - actin binding GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 2498 Hs			1 2527
+	Hs
		1028790 SPTB2_HUMAN (2-1057): 4.22e-45: 183: 19.77		LRRK2_HUMAN (1-2527): 0: 3019: 100.00
+	Hs
		1132269 GOGB1_HUMAN (1-1246): 2.97e-41: 170: 8.75		LRRK2_HUMAN (1-2527): 0: 3019: 100.00
+	Hs
		1209782 MYH2_HUMAN (1944-2472): 2.59e-13: 78.6: 10.02		LRRK2_HUMAN (1-2527): 0: 3019: 100.00
+	Hs
		555700 ACTN1_HUMAN (1867-2258): 2.66e-11: 71.6: 20.10		LRRK2_HUMAN (1-2527): 0: 3019: 100.00
+	Hs
		883909 CENPF_HUMAN (1798-2462): 6.8e-10: 67.4: 10.96		LRRK2_HUMAN (1-2527): 0: 3019: 100.00
+	Hs
		224724 ACTN4_HUMAN (1848-2224): 1.12e-09: 66.2: 20.15		LRRK2_HUMAN (1-2527): 0: 3019: 100.00
+	Mm
		1209204 PLEC_MOUSE (675-2408): 6.38e-30: 133: 8.54		LRRK2_MOUSE (1-2527): 0: 2872: 86.36
+	Hs
		1117383 SPTN1_HUMAN (1-2498): 0: 673: 98.84		LRRK1_HUMAN (866-1174): 1.81e-33: 144: 15.41
+	Hs
		1028785 SPTB2_HUMAN (2-1057): 4.22e-45: 183: 19.77		LRRK1_HUMAN (866-1174): 1.81e-33: 144: 15.41
+	Hs
		224720 ACTN4_HUMAN (1848-2224): 1.12e-09: 66.2: 20.15		LRRK1_HUMAN (866-1174): 1.81e-33: 144: 15.41