HitPredict

Interactor 1: STK10 (O94804)
Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase)
Gene: STK10

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 968 Hs			1 196
+	Hs
		296408 STK10_HUMAN (1-968): 0: 657: 100.00		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		296403 STK10_HUMAN (1-968): 0: 657: 100.00		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		296395 STK10_HUMAN (1-968): 0: 657: 100.00		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		647868 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		647858 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		647867 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		545213 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		436165 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		647872 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		647855 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		647856 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		900617 MARK2_HUMAN (19-757): 4.5e-163: 499: 16.08		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		545461 MARK2_HUMAN (19-757): 4.5e-163: 499: 16.08		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		436371 MARK2_HUMAN (19-757): 4.5e-163: 499: 16.08		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		892447 MARK2_HUMAN (19-757): 4.5e-163: 499: 16.08		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		894157 MARK2_HUMAN (19-757): 4.5e-163: 499: 16.08		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		564418 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		120307 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Hs
		564584 MARK2_HUMAN (19-757): 4.5e-163: 499: 16.08		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		120505 MARK2_HUMAN (19-757): 4.5e-163: 499: 16.08		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98