HitPredict

Interactor 1: RHBT3 (O94955)
Rho-related BTB domain-containing protein 3 (EC 3.6.1.-)
Gene: RHOBTB3

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.967

Property	Details
Experiments	18835386, 24145166, 28514442, 33961781, 35563538, 21145461, 30190310
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	BTB~Cullin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 611 Hs			1 768
+	Hs
		297618 RHBT1_HUMAN (31-611): 3.3e-116: 363: 18.45		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		214258 SPOP_HUMAN (219-582): 9.99e-72: 237: 15.51		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		893985 CDC42_HUMAN (31-209): 2.37e-74: 237: 18.85		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042881 KLH20_HUMAN (354-610): 1.47e-64: 224: 16.18		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041805 SPOPL_HUMAN (219-582): 3.06e-65: 220: 13.78		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		925262 RAC1_HUMAN (31-206): 5.82e-66: 215: 20.75		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		900452 RHOA_HUMAN (29-204): 6.83e-65: 213: 17.55		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042471 RHBT2_HUMAN (31-291): 2.27e-59: 212: 20.69		CUL3_HUMAN (1-768): 0: 951: 100.00
+	At
		1226186 BPM1_ARATH (244-606): 6.3e-88: 280: 16.67		CUL3A_ARATH (9-768): 0: 842: 51.45
+	At
		1341268 BPM2_ARATH (220-606): 8.59e-88: 280: 15.92		CUL3A_ARATH (9-768): 0: 842: 51.45
+	At
		186853 BPM3_ARATH (248-584): 7.03e-84: 270: 17.71		CUL3A_ARATH (9-768): 0: 842: 51.45
+	Dm
		1213841 RDX_DROME (187-582): 3.14e-68: 239: 14.84		Q8IP45_DROME (17-768): 0: 868: 69.08
+	At
		1226178 BPM1_ARATH (244-606): 6.3e-88: 280: 16.67		CUL3B_ARATH (9-768): 0: 826: 50.92
+	At
		51021 BPM6_ARATH (209-593): 1.24e-80: 261: 14.43		CUL3A_ARATH (9-768): 0: 842: 51.45
+	Dm
		1359790 RDX_DROME (187-582): 3.14e-68: 239: 14.84		Q9V475_DROME (2-768): 0: 861: 68.77
+	At
		186839 BPM3_ARATH (248-584): 7.03e-84: 270: 17.71		CUL3B_ARATH (9-768): 0: 826: 50.92
+	Hs
		214259 SPOP_HUMAN (219-582): 9.99e-72: 237: 15.51		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		893986 CDC42_HUMAN (31-209): 2.37e-74: 237: 18.85		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		297660 RHBT1_HUMAN (31-611): 3.3e-116: 363: 18.45		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		893984 CDC42_HUMAN (31-209): 2.37e-74: 237: 18.85		CUL1_HUMAN (18-768): 0: 707: 30.57