Protein: MAK5
ATP-dependent RNA helicase MAK5 (EC 3.6.4.13) (Maintenance of killer protein 5)

Gene: MAK5
Organism: Saccharomyces cerevisiae S288C
Interactions: 172
UniProt ID: P38112

Gene Ontology (top 5):
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

793520

HAS1
ATP-dependent RNA helicase HAS1

7

16

Small-scale

0.966

High

793549

DBP10
ATP-dependent RNA helicase DBP10

5

16

Small-scale

0.924

High

793473

CIC1
Proteasome-interacting protein CIC1

5

6

High-throughput

0.919

High

793545

YTM1
Ribosome biogenesis protein YTM1

5

20

High-throughput

0.919

High

793529

ERB1
Ribosome biogenesis protein ERB1

3

17

High-throughput

0.855

High

763823

SKI2
Antiviral helicase SKI2

2

16

High-throughput

0.759

High

513488

RL1A
Large ribosomal subunit protein uL1A

2

13

High-throughput

0.754

High

633154

MAK11
Protein MAK11

2

20

Small-scale

0.754

High

682259

SPB4
ATP-dependent rRNA helicase SPB4

2

19

High-throughput

0.754

High

793493

MTR4
ATP-dependent RNA helicase DOB1

2

17

Small-scale

0.754

High

793533

DBP9
ATP-dependent RNA helicase DBP9

2

15

Small-scale

0.754

High

791047

NOP4
Nucleolar protein 4

7

16

Small-scale

0.751

High

793538

NOP12
Nucleolar protein 12

6

20

High-throughput

0.730

High

793500

NSA1
Ribosome biogenesis protein NSA1

5

2

Small-scale

0.712

High

793517

NOG1
Nucleolar GTP-binding protein 1

5

9

Small-scale

0.712

High

793547

MAK21
Ribosome biogenesis protein MAK21

5

14

High-throughput

0.712

High

793479

NOC2
Nucleolar complex protein 2

5

3

Small-scale

0.704

High

793488

RLP7
Ribosome biogenesis protein RLP7

4

18

High-throughput

0.694

High

154156

RL36B
Large ribosomal subunit protein eL36B

1

5

High-throughput

0.691

High

569764

RL30
Large ribosomal subunit protein eL30

1

4

High-throughput

0.691

High

712548

RL8B
Large ribosomal subunit protein eL8B

1

14

High-throughput

0.691

High

758203

URB1
Nucleolar pre-ribosomal-associated protein 1

4

2

Small-scale

0.691

High

793489

NOP2
25S rRNA

4

11

Small-scale

0.691

High

793527

PUF6
Pumilio homology domain family member 6

4

6

Small-scale

0.687

High

793475

RPF1
Ribosome production factor 1

3

5

High-throughput

0.670

High

793531

RRP5
rRNA biogenesis protein RRP5

3

15

High-throughput

0.656

High

793505

PESC
Pescadillo homolog

3

9

High-throughput

0.650

High

780252

EBP2
rRNA-processing protein EBP2

3

5

High-throughput

0.646

High

793474

SSF1
Ribosome biogenesis protein SSF1

3

10

Small-scale

0.643

High

793491

LOC1
60S ribosomal subunit assembly/export protein LOC1

2

2

High-throughput

0.634

High

601026

RL8A
Large ribosomal subunit protein eL8A

1

14

High-throughput

0.618

High

632556

DBP3
ATP-dependent RNA helicase DBP3

1

15

Small-scale

0.618

High

637208

PWP1
Periodic tryptophan protein 1

1

20

High-throughput

0.618

High

746617

DRS1
ATP-dependent RNA helicase DRS1

1

16

High-throughput

0.618

High

781614

DBP7
ATP-dependent RNA helicase DBP7

1

16

High-throughput

0.618

High

793483

UTP7
U3 small nucleolar RNA-associated protein 7

1

20

High-throughput

0.618

High

793507

DBP6
ATP-dependent RNA helicase DBP6

1

16

Small-scale

0.618

High

793524

RUVB1
RuvB-like protein 1

1

6

High-throughput

0.618

High

793525

DHR1
Probable ATP-dependent RNA helicase DHR1

1

15

High-throughput

0.618

High

793532

HRQ1
ATP-dependent helicase HRQ1

1

17

Small-scale

0.618

High

410080

RL25
Large ribosomal subunit protein uL23

2

9

High-throughput

0.611

High

531704

RL4A
Large ribosomal subunit protein uL4A

2

8

High-throughput

0.611

High

569982

RL3
Large ribosomal subunit protein uL3

2

6

High-throughput

0.611

High

793484

NSA2
Ribosome biogenesis protein NSA2

2

2

High-throughput

0.594

High

475117

CYAA
Adenylate cyclase

2

3

High-throughput

0.588

High

455019

RS19A
Small ribosomal subunit protein eS19A

2

11

High-throughput

0.584

High

793470

ENP1
Essential nuclear protein 1

2

8

High-throughput

0.584

High

793490

UTP10
U3 small nucleolar RNA-associated protein 10

2

6

High-throughput

0.584

High

793511

NOP15
Ribosome biogenesis protein 15

2

20

High-throughput

0.584

High

793546

NOP53
Ribosome biogenesis protein NOP53

2

7

High-throughput

0.584

High

782316

RPF2
Ribosome biogenesis protein RPF2

2

3

High-throughput

0.571

High

793521

CLU
Clustered mitochondria protein 1

2

0

High-throughput

0.563

High

427238

RLA0
Large ribosomal subunit protein uL10

2

9

High-throughput

0.558

High

684695

RL5
Large ribosomal subunit protein uL18

2

4

High-throughput

0.558

High

594331

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

4

High-throughput

0.553

High

644914

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

7

High-throughput

0.553

High

792000

GBLP
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.553

High

793495

RS12
Small ribosomal subunit protein eS12

1

6

High-throughput

0.553

High

526479

HSP72
Heat shock protein SSA2

2

19

High-throughput

0.552

High

544577

SSB1
Ribosome-associated molecular chaperone SSB1

2

18

High-throughput

0.552

High

793485

SSB2
Ribosome-associated molecular chaperone SSB2

2

18

High-throughput

0.552

High

755080

GCN1
eIF-2-alpha kinase activator GCN1

2

16

High-throughput

0.537

High

432551

RL7A
Large ribosomal subunit protein uL30A

1

18

High-throughput

0.536

High

735258

KNS1
Dual specificity protein kinase KNS1

1

6

High-throughput

0.536

High

793514

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

4

High-throughput

0.536

High

793516

RL6A
Large ribosomal subunit protein eL6A

1

6

High-throughput

0.536

High

793518

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

17

High-throughput

0.536

High

793519

PKH3
Serine/threonine-protein kinase PKH3

1

17

High-throughput

0.536

High

793548

RL7B
Large ribosomal subunit protein uL30B

1

18

High-throughput

0.536

High

383659

RS17A
Small ribosomal subunit protein eS17A

2

7

High-throughput

0.533

High

511177

RL20B
Large ribosomal subunit protein eL20B

2

5

High-throughput

0.533

High

512963

RS8A
Small ribosomal subunit protein eS8A

2

8

High-throughput

0.533

High

753324

RS3A1
Small ribosomal subunit protein eS1A

2

10

High-throughput

0.533

High

437915

KAPC
cAMP-dependent protein kinase type 3

1

11

High-throughput

0.501

High

793482

EDC2
Enhancer of mRNA-decapping protein 2

1

0

High-throughput

0.493

High

511779

RS24A
Small ribosomal subunit protein eS24A

1

6

High-throughput

0.489

High

721868

XPO1
Exportin-1

1

18

High-throughput

0.489

High

793471

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

4

High-throughput

0.489

High

793553

RS22B
Small ribosomal subunit protein uS8B

1

9

High-throughput

0.489

High

793502

PDK2
[Pyruvate dehydrogenase

1

0

High-throughput

0.480

High

149717

RS9A
Small ribosomal subunit protein uS4A

1

11

High-throughput

0.479

High

409720

RL24A
Large ribosomal subunit protein eL24A

1

9

High-throughput

0.479

High

433595

RL26A
Large ribosomal subunit protein uL24A

1

10

High-throughput

0.479

High

434358

RL15A
Large ribosomal subunit protein eL15A

1

4

High-throughput

0.479

High

434551

RL22A
Large ribosomal subunit protein eL22A

1

5

High-throughput

0.479

High

435032

RS3
Small ribosomal subunit protein uS3

1

8

High-throughput

0.479

High

435918

RS13
Small ribosomal subunit protein uS15

1

8

High-throughput

0.479

High

441865

RS14A
Small ribosomal subunit protein uS11A

1

9

High-throughput

0.479

High

512061

RS4A
Small ribosomal subunit protein eS4A

1

3

High-throughput

0.479

High

512397

RS6A
Small ribosomal subunit protein eS6A

1

10

High-throughput

0.479

High

513674

RL2A
Large ribosomal subunit protein uL2A

1

10

High-throughput

0.479

High

534102

MAK16
Protein MAK16

1

5

High-throughput

0.479

High

579248

HSC82
ATP-dependent molecular chaperone HSC82

1

10

High-throughput

0.479

High

670601

SIS1
Protein SIS1

1

7

High-throughput

0.479

High

672879

RRP43
Exosome complex component RRP43

1

2

High-throughput

0.479

High

674574

RS2
Small ribosomal subunit protein uS5

1

11

High-throughput

0.479

High

677191

SPB1
27S pre-rRNA

1

11

High-throughput

0.479

High

677363

KRR1
KRR1 small subunit processome component

1

9

High-throughput

0.479

High

677920

YCQ6
Uncharacterized protein YCR016W

1

1

High-throughput

0.479

High

689407

RS7A
Small ribosomal subunit protein eS7A

1

7

High-throughput

0.479

High

750067

MRT4
Ribosome assembly factor MRT4

1

9

High-throughput

0.479

High

763061

RRP1
Ribosomal RNA-processing protein 1

1

11

High-throughput

0.479

High

763562

UTP20
U3 small nucleolar RNA-associated protein 20

1

1

High-throughput

0.479

High

778283

RS27A
Small ribosomal subunit protein eS27A

1

6

High-throughput

0.479

High

785909

LONM
Lon protease homolog, mitochondrial

1

10

High-throughput

0.479

High

793476

RRP8
25S rRNA

1

4

High-throughput

0.479

High

793480

DPO5
rDNA transcriptional regulator POL5

1

2

High-throughput

0.479

High

793494

URB2
Nucleolar pre-ribosomal-associated protein 2

1

1

High-throughput

0.479

High

793504

UTP22
U3 small nucleolar RNA-associated protein 22

1

3

High-throughput

0.479

High

793506

YG5X
Putative methyltransferase YGR283C

1

3

High-throughput

0.479

High

793508

NOG2
Nucleolar GTP-binding protein 2

1

17

High-throughput

0.479

High

793509

NOP13
Nucleolar protein 13

1

15

High-throughput

0.479

High

793510

NAT10
RNA cytidine acetyltransferase

1

6

High-throughput

0.479

High

793515

RS15
Small ribosomal subunit protein uS19

1

6

High-throughput

0.479

High

793528

UTP14
U3 small nucleolar RNA-associated protein 14

1

5

High-throughput

0.479

High

793534

NOC4
Nucleolar complex protein 4

1

14

High-throughput

0.479

High

793535

URN1
Pre-mRNA-splicing factor URN1

1

1

High-throughput

0.479

High

793537

RLP24
Ribosome biogenesis protein RLP24

1

9

Small-scale

0.479

High

793539

BRX1
Ribosome biogenesis protein BRX1

1

20

High-throughput

0.479

High

793540

REXO4
RNA exonuclease 4

1

4

High-throughput

0.479

High

793543

RS10A
Small ribosomal subunit protein eS10A

1

9

High-throughput

0.479

High

793544

BMS1
Ribosome biogenesis protein BMS1

1

6

High-throughput

0.479

High

793550

NOP58
Nucleolar protein 58

1

12

High-throughput

0.479

High

793552

RRP12
Ribosomal RNA-processing protein 12

1

5

High-throughput

0.479

High

793554

NOP14
Nucleolar complex protein 14

1

3

High-throughput

0.479

High

744550

FADH
S-(hydroxymethyl)glutathione dehydrogenase

1

2

High-throughput

0.470

High

793541

NOP8
60S ribosome subunit biogenesis protein NOP8

1

0

High-throughput

0.458

High

392600

HSP82
ATP-dependent molecular chaperone HSP82

1

10

High-throughput

0.445

High

453552

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.445

High

523697

HSP71
Heat shock protein SSA1

1

19

High-throughput

0.445

High

592188

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.445

High

645393

XRN1
5'-3' exoribonuclease 1

1

5

High-throughput

0.445

High

726958

HS104
Heat shock protein 104

1

3

High-throughput

0.445

High

436387

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

6

High-throughput

0.437

High

503000

RS22A
Small ribosomal subunit protein uS8A

1

9

High-throughput

0.437

High

504173

RL31A
Large ribosomal subunit protein eL31A

1

13

High-throughput

0.437

High

513353

RL23B
Large ribosomal subunit protein uL14B

1

2

High-throughput

0.437

High

514600

RS18A
Small ribosomal subunit protein uS13A

1

7

High-throughput

0.437

High

561466

TBP
TATA-box-binding protein

1

3

High-throughput

0.437

High

655440

RS3A2
Small ribosomal subunit protein eS1B

1

10

High-throughput

0.437

High

706870

TF2B
Transcription initiation factor IIB

1

8

High-throughput

0.437

High

734943

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

5

High-throughput

0.437

High

747317

RSSA1
Small ribosomal subunit protein uS2A

1

15

High-throughput

0.437

High

751384

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

4

High-throughput

0.437

High

793469

AIM4
Altered inheritance of mitochondria protein 4

1

1

High-throughput

0.437

High

793472

RS20
Small ribosomal subunit protein uS10

1

9

High-throughput

0.437

High

793478

LAA1
AP-1 accessory protein LAA1

1

7

High-throughput

0.437

High

793486

ULP2
Ubiquitin-like-specific protease 2

1

7

High-throughput

0.437

High

793487

DSN1
Kinetochore-associated protein DSN1

1

6

High-throughput

0.437

High

793492

SAD1
Pre-mRNA-splicing factor SAD1

1

16

High-throughput

0.437

High

793501

LSG1
Large subunit GTPase 1

1

17

High-throughput

0.437

High

793503

EIF2A
Eukaryotic translation initiation factor 2A

1

6

High-throughput

0.437

High

793512

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.437

High

793513

H3
Histone H3

1

20

High-throughput

0.437

High

793522

BUL2
Ubiquitin ligase-binding protein BUL2

1

1

Small-scale

0.437

High

793526

VMS1
tRNA endonuclease VMS1

1

3

High-throughput

0.437

High

793530

YM91
Putative methyltransferase YMR310C

1

3

High-throughput

0.437

High

793536

VAM6
Vacuolar morphogenesis protein 6

1

6

High-throughput

0.437

High

793542

SGO1
Shugoshin

1

5

High-throughput

0.437

High

793551

RL21B
Large ribosomal subunit protein eL21B

1

3

High-throughput

0.437

High

792772

ANM1
Protein arginine N-methyltransferase 1

1

7

High-throughput

0.417

High

394476

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.407

High

403478

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

10

High-throughput

0.407

High

793477

CAJ1
Protein CAJ1

1

6

High-throughput

0.407

High

793496

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

4

High-throughput

0.407

High

793497

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

4

High-throughput

0.407

High

536011

SEC7
ADP-ribosylation factor guanine nucleotide-exchange factor SEC7

2

0

High-throughput

0.307

High

793523

INP2
Inheritance of peroxisomes protein 2

2

0

High-throughput

0.307

High

732786

MET22
3'(2'),5'-bisphosphate nucleotidase

1

0

High-throughput

0.269

Low

793499

YGO0
Uncharacterized membrane protein YGL140C

1

0

High-throughput

0.249

Low

793481

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.232

Low

793498

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025