HitPredict

Interactor 1: AP2A2 (O94973)
AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)
Gene: AP2A2

Interactor 2: CLH1 (Q00610)
Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)
Gene: CLTC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.854

The method score is based on:

Property	Details
Experiments	26496610, 9280305, 17052248
Identification Methods	affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Alpha_adaptinC2~Clathrin
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006886 - intracellular protein transport GO:0019901 - protein kinase binding GO:0030669 - clathrin-coated endocytic vesicle membrane and 4 others more... GO:0036020 - endolysosome membrane GO:0045334 - clathrin-coated endocytic vesicle GO:0072583 - clathrin-dependent endocytosis GO:0097718 - disordered domain specific binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1	939
Hs

1	1675

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024