Protein: SH3G1
Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1)

Gene: SH3G1, SH3GL1
Organism: Homo sapiens
Interactions: 144
UniProt ID: Q99961

Gene Ontology (top 5):
GO:0002102 - podosome
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006897 - endocytosis
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1408372

SH3G3
Endophilin-A3

7

17

Small-scale

0.971

High

1408371

SH3G2
Endophilin-A1

8

17

Small-scale

0.971

High

1408370

SH3G1
Endophilin-A2

8

16

Small-scale

0.967

High

1408374

SH24A
SH2 domain-containing protein 4A

5

20

High-throughput

0.931

High

1017536

RHG08
Rho GTPase-activating protein 8

5

20

Small-scale

0.920

High

628643

CAP7
Azurocidin

4

4

High-throughput

0.797

High

193300

SOCS1
Suppressor of cytokine signaling 1

2

20

High-throughput

0.783

High

1061284

RHG01
Rho GTPase-activating protein 1

2

20

High-throughput

0.783

High

1050710

DYN1
Dynamin-1

2

20

Small-scale

0.778

High

72896

B1AHC3
PRR5-ARHGAP8 readthrough

2

20

High-throughput

0.759

High

85492

B7ZMA4
LOC553158 protein

2

20

High-throughput

0.757

High

1316653

Q8IZM6
BCH domain-containing Cdc42GAP-like protein

1

20

Small-scale

0.724

High

170311

AURKA
Aurora kinase A

4

6

High-throughput

0.694

High

1271210

DPPA4
Developmental pluripotency-associated protein 4

10

4

High-throughput

0.691

High

572847

NCF1
Neutrophil cytosol factor 1

1

20

High-throughput

0.691

High

1356984

PDC6I
Programmed cell death 6-interacting protein

4

20

Small-scale

0.674

High

1251106

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

3

6

High-throughput

0.667

High

1209567

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

3

11

Small-scale

0.656

High

1102638

MTA1
Metastasis-associated protein MTA1

3

3

High-throughput

0.654

High

1214845

EEIG1
Early estrogen-induced gene 1 protein

3

1

High-throughput

0.654

High

1370621

GPKOW
G-patch domain and KOW motifs-containing protein

4

1

High-throughput

0.629

High

1408380

ITSN2
Intersectin-2

1

20

High-throughput

0.621

High

212785

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

17

Small-scale

0.618

High

541659

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

1157045

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.618

High

1258039

RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

1

18

Small-scale

0.618

High

1408373

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

633780

PSB1
Proteasome subunit beta type-1

2

3

High-throughput

0.606

High

1308877

CCD50
Coiled-coil domain-containing protein 50

2

1

High-throughput

0.606

High

474931

VIME
Vimentin

2

20

High-throughput

0.600

High

63255

VP37C
Vacuolar protein sorting-associated protein 37C

3

20

High-throughput

0.597

High

1380440

MAL2
Protein MAL2

3

2

High-throughput

0.597

High

1408379

SPG21
Maspardin

2

0

High-throughput

0.580

High

896871

DYN2
Dynamin-2

1

20

Small-scale

0.575

High

1408384

DYN3
Dynamin-3

1

20

Small-scale

0.575

High

456976

CO8G
Complement component C8 gamma chain

2

2

High-throughput

0.574

High

1384251

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

Small-scale

0.573

High

161076

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

20

Small-scale

0.561

High

1308746

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

1

20

High-throughput

0.561

High

1380635

FBX32
F-box only protein 32

1

2

Small-scale

0.561

High

1257314

RHEX
Regulator of hemoglobinization and erythroid cell expansion protein

2

1

High-throughput

0.553

High

1346725

SCAM5
Secretory carrier-associated membrane protein 5

2

1

High-throughput

0.553

High

1388170

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

2

1

High-throughput

0.553

High

274725

DNJB6
DnaJ homolog subfamily B member 6

1

5

High-throughput

0.536

High

300219

GLRX3
Glutaredoxin-3

1

2

High-throughput

0.536

High

611960

RL35A
Large ribosomal subunit protein eL33

1

3

High-throughput

0.536

High

733423

CCR1
C-C chemokine receptor type 1

1

2

High-throughput

0.536

High

965847

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

8

High-throughput

0.536

High

1325131

MILK1
MICAL-like protein 1

1

20

High-throughput

0.536

High

1408375

EMAL4
Echinoderm microtubule-associated protein-like 4

1

4

High-throughput

0.536

High

1408377

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.536

High

1408385

NTNG1
Netrin-G1

1

1

High-throughput

0.536

High

1394595

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

11

Small-scale

0.527

High

843914

HD
Huntingtin

1

11

High-throughput

0.515

High

943119

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

135692

DNM1L
Dynamin-1-like protein

1

20

Small-scale

0.508

High

155871

DPYL4
Dihydropyrimidinase-related protein 4

1

3

High-throughput

0.508

High

990661

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.508

High

1163803

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

10

High-throughput

0.508

High

1365286

SEPT8
Septin-8

1

3

High-throughput

0.508

High

215945

SYNJ1
Synaptojanin-1

1

20

Small-scale

0.501

High

706278

S10A2
Protein S100-A2

1

6

High-throughput

0.489

High

1328924

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

5

High-throughput

0.489

High

1403223

MA7D2
MAP7 domain-containing protein 2

1

18

High-throughput

0.489

High

1408383

ANGL2
Angiopoietin-related protein 2

1

3

High-throughput

0.489

High

714383

PML
Protein PML

1

5

High-throughput

0.481

High

71039

SMTL1
Smoothelin-like protein 1

1

17

High-throughput

0.479

High

210602

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

2

High-throughput

0.479

High

315941

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

346245

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

374880

RASH
GTPase HRas

1

19

Small-scale

0.479

High

375882

RASK
GTPase KRas

1

20

High-throughput

0.479

High

466854

ACM2
Muscarinic acetylcholine receptor M2

1

20

Small-scale

0.479

High

466955

ACM4
Muscarinic acetylcholine receptor M4

1

20

Small-scale

0.479

High

477194

ADA2A
Alpha-2A adrenergic receptor

1

20

Small-scale

0.479

High

537790

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.479

High

556305

CADH1
Cadherin-1

1

9

High-throughput

0.479

High

612348

ADA2B
Alpha-2B adrenergic receptor

1

20

Small-scale

0.479

High

613443

VINC
Vinculin

1

11

High-throughput

0.479

High

717961

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

2

High-throughput

0.479

High

767317

MERL
Merlin

1

15

High-throughput

0.479

High

770813

HRH1
Histamine H1 receptor

1

20

Small-scale

0.479

High

861267

MAP1B
Microtubule-associated protein 1B

1

13

High-throughput

0.479

High

862411

YAP1
Transcriptional coactivator YAP1

1

17

High-throughput

0.479

High

876976

KC1A
Casein kinase I isoform alpha

1

4

High-throughput

0.479

High

896624

VASP
Vasodilator-stimulated phosphoprotein

1

16

High-throughput

0.479

High

966802

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

976518

RB11A
Ras-related protein Rab-11A

1

8

High-throughput

0.479

High

978252

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

1033186

EWS
RNA-binding protein EWS

1

6

High-throughput

0.479

High

1033761

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

1049715

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1059940

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

10

Small-scale

0.479

High

1138556

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1156835

E2F4
Transcription factor E2F4

1

1

High-throughput

0.479

High

1255249

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.479

High

1289578

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1347850

RIN3
Ras and Rab interactor 3

1

20

High-throughput

0.479

High

1350427

BICD2
Protein bicaudal D homolog 2

1

20

High-throughput

0.479

High

1363831

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

3

High-throughput

0.479

High

1364552

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

1368465

CBP
CREB-binding protein

1

17

Small-scale

0.479

High

1391164

BICD1
Protein bicaudal D homolog 1

1

20

High-throughput

0.479

High

1400329

FMNL2
Formin-like protein 2

1

4

High-throughput

0.479

High

1407834

ANM1
Protein arginine N-methyltransferase 1

1

4

Small-scale

0.479

High

1408382

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1408386

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

1

20

High-throughput

0.479

High

1408387

HRH3
Histamine H3 receptor

1

20

Small-scale

0.479

High

85459

B7ZLH0
FAM22F protein

1

4

High-throughput

0.470

High

1045040

PRB3
Basic salivary proline-rich protein 3

1

18

High-throughput

0.470

High

884785

SYSC
Serine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

1151379

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1252951

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1330914

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

181163

AXIN1
Axin-1

1

3

High-throughput

0.457

High

963462

STXB1
Syntaxin-binding protein 1

1

2

High-throughput

0.457

High

1007772

RAE1L
mRNA export factor RAE1

1

4

High-throughput

0.445

High

1315708

DND1
Dead end protein homolog 1

1

9

High-throughput

0.445

High

1351956

RBCC1
RB1-inducible coiled-coil protein 1

1

20

High-throughput

0.445

High

1408378

DDX28
Probable ATP-dependent RNA helicase DDX28

1

5

High-throughput

0.445

High

51332

NTM2F
NUT family member 2F

1

4

High-throughput

0.439

High

260366

BRD4
Bromodomain-containing protein 4

1

5

High-throughput

0.437

High

279469

TULP3
Tubby-related protein 3

1

6

High-throughput

0.437

High

372969

MYC
Myc proto-oncogene protein

1

9

High-throughput

0.437

High

418389

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

569044

ADRB3
Beta-3 adrenergic receptor

1

7

Small-scale

0.437

High

589521

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

769004

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

771643

DRD3
D(3) dopamine receptor

1

18

Small-scale

0.437

High

945081

RAB25
Ras-related protein Rab-25

1

8

High-throughput

0.437

High

1096800

RFA4
Replication protein A 30 kDa subunit

1

5

High-throughput

0.437

High

1226505

DCA15
DDB1- and CUL4-associated factor 15

1

2

High-throughput

0.437

High

1229055

RNF43
E3 ubiquitin-protein ligase RNF43

1

16

High-throughput

0.437

High

1233447

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.437

High

598766

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

1391023

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

261259

NSMA
Sphingomyelin phosphodiesterase 2

1

2

High-throughput

0.407

High

330291

VENTX
Homeobox protein VENTX

1

8

High-throughput

0.407

High

1104070

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.407

High

1408376

ITM2C
Integral membrane protein 2C

1

5

High-throughput

0.407

High

1389681

SGF29
SAGA-associated factor 29

4

0

High-throughput

0.360

High

1402858

GPX7
Glutathione peroxidase 7

2

0

High-throughput

0.328

High

1408381

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.282

High


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Last updated: 11Aug2025