HitPredict

Interactor 1: ARHGF (O94989)
Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF)
Gene: ARHGEF15

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32203420
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0051496 - positive regulation of stress fiber assembly GO:0098794 - postsynapse GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 841 Hs			1 193
+	Hs
		302669 ARHGF_HUMAN (1-841): 3.16e-126: 401: 100.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		900690 NGEF_HUMAN (177-825): 8.33e-113: 362: 28.96		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925436 NGEF_HUMAN (177-825): 8.33e-113: 362: 28.96		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		894213 NGEF_HUMAN (177-825): 8.33e-113: 362: 28.96		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		900786 ARHGQ_HUMAN (6-826): 2.32e-106: 349: 24.11		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		900663 ARHGJ_HUMAN (60-836): 1.87e-106: 347: 25.97		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925512 ARHGQ_HUMAN (6-826): 2.32e-106: 349: 24.11		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		925416 ARHGJ_HUMAN (60-836): 1.87e-106: 347: 25.97		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		915832 NGEF_HUMAN (177-825): 8.33e-113: 362: 28.96		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		925374 DNMBP_HUMAN (9-630): 1.43e-100: 344: 18.43		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		925527 SPT13_HUMAN (177-804): 5.74e-107: 344: 14.71		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		894301 ARHGQ_HUMAN (6-826): 2.32e-106: 349: 24.11		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		894320 FGD4_HUMAN (183-831): 1.71e-107: 349: 15.85		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		951095 DNMBP_HUMAN (9-630): 1.43e-100: 344: 18.43		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		894149 DNMBP_HUMAN (9-630): 1.43e-100: 344: 18.43		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		894323 SPT13_HUMAN (177-804): 5.74e-107: 344: 14.71		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		915891 ARHGQ_HUMAN (6-826): 2.32e-106: 349: 24.11		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		892443 DNMBP_HUMAN (9-630): 1.43e-100: 344: 18.43		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		894047 ITSN1_HUMAN (3-755): 5.12e-98: 337: 16.77		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		894169 FGD2_HUMAN (335-831): 5.53e-104: 337: 18.02		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33