HitPredict

Interactor 1: KLHL2 (O95198)
Kelch-like protein 2 (Actin-binding protein Mayven)
Gene: KLHL2

Interactor 2: ACTZ (P61163)
Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog)
Gene: ACTR1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 593 Hs			1 376
+	Hs
		307157 KLHL2_HUMAN (1-593): 0: 574: 100.00		ACTY_HUMAN (1-376): 0: 728: 90.43
+	Dm
		361180 KELC_DROME (13-593): 1.56e-177: 543: 59.90		ACT4_DROME (11-376): 0: 612: 52.70
+	Hs
		307166 KLHL2_HUMAN (1-593): 0: 574: 100.00		ACTC_HUMAN (5-376): 0: 576: 52.93
+	Hs
		915528 KLHL3_HUMAN (12-593): 0: 546: 77.66		ACTA_HUMAN (5-376): 0: 576: 52.66
+	Hs
		891883 KLHL7_HUMAN (46-590): 2.67e-146: 436: 32.30		ACTB_HUMAN (7-376): 0: 580: 52.41
+	Mm
		659359 IPP_MOUSE (401-593): 1.8e-47: 176: 35.15		ACTS_MOUSE (5-376): 0: 576: 52.39
+	Hs
		933075 KLH20_HUMAN (494-593): 2.37e-25: 112: 45.00		ACTS_HUMAN (5-376): 0: 576: 52.39
+	Rn
		892235 KLH17_RAT (485-593): 3.5e-18: 90.3: 38.53		ACTB_RAT (7-376): 0: 580: 52.41
+	Mm
		929797 KLH17_MOUSE (485-593): 3.5e-18: 90.3: 38.53		ACTG_MOUSE (7-376): 0: 580: 52.67