HitPredict

Interactor 1: IPO7 (O95373)
Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7)
Gene: IPO7

Interactor 2: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.920

Property	Details
Experiments	9214382, 35271311, 27114554, 11024021, 10944119
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Cse1~Ras, IBN_N~Ras
Common GO terms	GO:0005635 - nuclear envelope GO:0005643 - nuclear pore GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006606 - protein import into nucleus and 1 others more... GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1038 Hs			1 216
+	Hs
		178143 IPO8_HUMAN (1-1032): 0: 822: 64.41		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		874484 XPO2_HUMAN (2-921): 1.6e-168: 521: 17.50		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Sc
		698861 NMD5_YEAST (1-996): 1.71e-155: 489: 23.11		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Dm
		1373317 Q9VRV8_DROME (3-892): 3.74e-134: 429: 12.47		RANL_DROME (1-210): 2.56e-93: 273: 60.48
+	At
		784988 TNPO1_ARATH (3-905): 1.66e-130: 419: 14.72		RAN1_ARATH (1-216): 1.39e-95: 279: 73.52
+	Sc
		698930 SXM1_YEAST (4-1001): 3.12e-131: 422: 22.04		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Sc
		698750 CSE1_YEAST (2-981): 1.98e-130: 421: 15.14		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Sp
		142272 CSE1_SCHPO (3-903): 9.39e-128: 414: 16.67		SPI1_SCHPO (1-214): 1.23e-84: 251: 80.84
+	Hs
		919198 TNPO1_HUMAN (12-892): 7.7e-134: 428: 13.08		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	At
		784992 IMB1_ARATH (1-892): 9.86e-118: 384: 12.16		RAN1_ARATH (1-216): 1.39e-95: 279: 73.52
+	Sc
		698999 CSE1_YEAST (2-981): 1.98e-130: 421: 15.14		GSP2_YEAST (1-214): 1.18e-80: 241: 79.72
+	Hs
		155560 TNPO2_HUMAN (12-903): 3.4e-128: 413: 12.41		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		919299 IPO11_HUMAN (1-954): 8.02e-127: 412: 15.94		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Sc
		698917 KA120_YEAST (6-891): 1.55e-122: 401: 15.13		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	At
		784999 IMB1_ARATH (1-892): 9.86e-118: 384: 12.16		RAN2_ARATH (1-215): 1.36e-88: 261: 74.77
+	Sc
		699016 KA120_YEAST (6-891): 1.55e-122: 401: 15.13		GSP2_YEAST (1-214): 1.18e-80: 241: 79.72
+	Hs
		127238 IPO5_HUMAN (4-955): 1.57e-121: 400: 11.44		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		919222 IPO9_HUMAN (4-996): 5e-121: 398: 15.05		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	At
		1210454 IMB1_ARATH (1-892): 9.86e-118: 384: 12.16		RAN3_ARATH (1-215): 9.1e-84: 249: 74.31
+	Hs
		919077 IMB1_HUMAN (5-785): 2.49e-114: 375: 12.82		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00