Protein: JIP3
C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3)

Gene: JIP3, MAPK8IP3
Organism: Homo sapiens
Interactions: 63
UniProt ID: Q9UPT6

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005078 - MAP-kinase scaffold activity
GO:0005737 - cytoplasm
GO:0008432 - JUN kinase binding
GO:0016192 - vesicle-mediated transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1060590

KLC1
Kinesin light chain 1

4

11

Small-scale

0.903

High

244031

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

2

18

High-throughput

0.811

High

332461

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

2

11

High-throughput

0.811

High

1432026

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

2

11

High-throughput

0.811

High

1429720

KLC2
Kinesin light chain 2

1

13

Small-scale

0.724

High

886338

ARL4D
ADP-ribosylation factor-like protein 4D

1

20

High-throughput

0.698

High

923402

MK10
Mitogen-activated protein kinase 10

3

20

Small-scale

0.679

High

853755

MK08
Mitogen-activated protein kinase 8

3

20

Small-scale

0.676

High

1211066

ARH
Low density lipoprotein receptor adapter protein 1

3

8

High-throughput

0.671

High

1103742

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

3

9

Small-scale

0.670

High

1411010

ST4A1
Sulfotransferase 4A1

3

1

High-throughput

0.665

High

853869

MK09
Mitogen-activated protein kinase 9

3

20

Small-scale

0.651

High

162057

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

3

20

Small-scale

0.646

High

1452953

ARP10
Actin-related protein 10

2

18

High-throughput

0.628

High

1462571

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

2

8

High-throughput

0.628

High

401708

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

19

Small-scale

0.624

High

1038377

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

20

Small-scale

0.624

High

1051083

FAK1
Focal adhesion kinase 1

2

20

Small-scale

0.624

High

1406397

M3K5
Mitogen-activated protein kinase kinase kinase 5

2

20

Small-scale

0.624

High

975325

ARF6
ADP-ribosylation factor 6

1

10

Small-scale

0.618

High

1123879

DCTN1
Dynactin subunit 1

2

19

Small-scale

0.611

High

292406

RA51D
DNA repair protein RAD51 homolog 4

2

4

High-throughput

0.606

High

64917

RCCD1
RCC1 domain-containing protein 1

3

8

High-throughput

0.604

High

1436846

WDR54
WD repeat-containing protein 54

2

0

High-throughput

0.602

High

1460701

DCTN4
Dynactin subunit 4

2

0

High-throughput

0.602

High

1132516

SMCO1
Single-pass membrane and coiled-coil domain-containing protein 1

2

1

High-throughput

0.574

High

1293723

ZN575
Zinc finger protein 575

2

5

High-throughput

0.553

High

900228

FXR1
RNA-binding protein FXR1

1

13

High-throughput

0.541

High

1056004

RAD51
DNA repair protein RAD51 homolog 1

1

4

High-throughput

0.541

High

1446622

RIC8A
Chaperone Ric-8A

1

1

High-throughput

0.541

High

1110767

DCTN2
Dynactin subunit 2

1

3

High-throughput

0.536

High

1370610

FGF14
Fibroblast growth factor 14

1

3

High-throughput

0.536

High

853913

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

2

20

Small-scale

0.533

High

1123553

BTG3
Protein BTG3

1

0

High-throughput

0.518

High

49355

SHOT1
Shootin-1

1

0

High-throughput

0.513

High

298246

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.513

High

1314567

TM192
Transmembrane protein 192

1

0

High-throughput

0.513

High

1462572

MTL5
Tesmin

1

0

High-throughput

0.513

High

557530

SRC
Proto-oncogene tyrosine-protein kinase Src

1

15

Small-scale

0.501

High

1159144

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

5

Small-scale

0.501

High

874017

NRIP1
Nuclear receptor-interacting protein 1

1

1

High-throughput

0.494

High

832836

BCL6
B-cell lymphoma 6 protein

1

5

Small-scale

0.489

High

915035

AK1C2
Aldo-keto reductase family 1 member C2

1

2

High-throughput

0.489

High

243303

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.479

High

412819

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

414863

P53
Cellular tumor antigen p53

1

7

Small-scale

0.479

High

858731

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

20

Small-scale

0.479

High

920369

PLK1
Serine/threonine-protein kinase PLK1

1

4

High-throughput

0.479

High

956028

RAB8A
Ras-related protein Rab-8A

1

11

Small-scale

0.479

High

956804

RAB10
Ras-related protein Rab-10

1

11

Small-scale

0.479

High

1067842

EP300
Histone acetyltransferase p300

1

16

High-throughput

0.479

High

1098865

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

20

Small-scale

0.479

High

1352643

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

20

Small-scale

0.479

High

1369179

KAT2A
Histone acetyltransferase KAT2A

1

20

High-throughput

0.479

High

255300

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

8

High-throughput

0.445

High

935300

TERA
Transitional endoplasmic reticulum ATPase

1

9

High-throughput

0.445

High

954641

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

1

High-throughput

0.445

High

1398404

CEP63
Centrosomal protein of 63 kDa

1

20

High-throughput

0.445

High

1461999

ALK
ALK tyrosine kinase receptor

1

20

Small-scale

0.437

High

640330

EPHA1
Ephrin type-A receptor 1

1

13

High-throughput

0.407

High

1288946

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

14

High-throughput

0.407

High

1460833

CC018
Uncharacterized protein C3orf18

1

1

High-throughput

0.407

High

133388

DCTN6
Dynactin subunit 6

2

0

High-throughput

0.328

High


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Last updated: 11Aug2025