HitPredict

Interactor 1: ACTN3 (O88990)
Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein)
Gene: ACTN3

Interactor 2: NRAP (Q80XB4)
Nebulin-related-anchoring protein (N-RAP)
Gene: NRAP

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	12692149
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CH~LIM
Common GO terms	GO:0030018 - Z disc GO:0051015 - actin filament binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 900 Mm			1 1728
+	Hs
		773758 ACTN2_HUMAN (23-900): 0: 630: 81.44		NRAP_HUMAN (1-1728): 0: 1895: 86.14
+	Hs
		73650 B2R8Y4_HUMAN (1-900): 0: 653: 96.56		NEBL_HUMAN (2-263): 6.3e-19: 95.8: 14.53
+	Hs
		302163 ACTN3_HUMAN (1-900): 0: 650: 96.45		NEBL_HUMAN (2-263): 6.3e-19: 95.8: 14.53
+	Hs
		555601 ACTN1_HUMAN (17-900): 0: 671: 78.29		CSRP1_HUMAN (4-142): 3.48e-13: 72: 16.35
+	Dm
		612386 ACTN_DROME (14-900): 0: 626: 66.23		LASP1_DROME (677-801): 1.47e-24: 113: 20.74
+	Hs
		773715 ACTN2_HUMAN (23-900): 0: 630: 81.44		CSRP3_HUMAN (5-159): 6.09e-14: 74.3: 17.34
+	Hs
		224823 ACTN4_HUMAN (24-900): 0: 624: 74.60		LIMA1_HUMAN (4-78): 1.3e-13: 78.1: 26.67
+	Hs
		1117362 SPTN1_HUMAN (288-742): 1.29e-15: 84: 15.32		LASP1_HUMAN (1375-1452): 1.37e-15: 80.8: 27.85
+	Hs
		1117522 SPTN1_HUMAN (288-742): 1.29e-15: 84: 15.32		LIMA1_HUMAN (4-78): 1.3e-13: 78.1: 26.67
+	Hs
		1117396 SPTN1_HUMAN (288-742): 1.29e-15: 84: 15.32		MICA3_HUMAN (4-58): 7.22e-12: 73.1: 29.83
+	Hs
		1028906 SPTB2_HUMAN (258-767): 8.71e-11: 68.5: 11.52		LIMA1_HUMAN (4-78): 1.3e-13: 78.1: 26.67
+	Hs
		1028804 SPTB2_HUMAN (258-767): 8.71e-11: 68.5: 11.52		MICA3_HUMAN (4-58): 7.22e-12: 73.1: 29.83