HitPredict

Interactor 1: AHSA1 (O95433)
Activator of 90 kDa heat shock protein ATPase homolog 1 (AHA1) (p38)
Gene: AHSA1

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.944

Property	Details
Experiments	26693507, 35271311, 25036637, 25486457, 20226818, 20618441
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, molecular sieving
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Aha1_N~HSP90, AHSA1~HSP90
Common GO terms	GO:0005829 - cytosol GO:0006457 - protein folding GO:0045296 - cadherin binding GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 338 Hs			1 724
+	Hs
		111931 AHSA1_HUMAN (1-338): 1.63e-179: 502: 100.00		K9JA46_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		314199 AHSA1_HUMAN (1-338): 1.63e-179: 502: 100.00		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		314218 AHSA1_HUMAN (1-338): 1.63e-179: 502: 100.00		ENPL_HUMAN (3-693): 0: 917: 46.44
+	Hs
		431992 AHSA2_HUMAN (1-331): 7.7e-116: 339: 40.96		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Ce
		1090263 Q93168_CAEEL (1-337): 5.42e-136: 391: 36.84		HSP90_CAEEL (8-724): 0: 976: 74.34
+	Sp
		784797 YNY8_SCHPO (15-337): 2.25e-128: 372: 28.82		HSP90_SCHPO (10-724): 0: 929: 62.48
+	Dm
		1360454 Q9V9Q4_DROME (1-337): 1.24e-146: 419: 42.17		Q9VAY2_DROME (4-692): 0: 848: 46.14
+	Sc
		367120 AHA1_YEAST (21-337): 7.04e-107: 317: 25.58		HSP82_YEAST (12-724): 0: 927: 61.26
+	Sc
		544634 AHA1_YEAST (21-337): 7.04e-107: 317: 25.58		HSC82_YEAST (13-724): 0: 922: 60.22
+	Sc
		366685 HCH1_YEAST (21-164): 1.16e-43: 149: 25.00		HSP82_YEAST (12-724): 0: 927: 61.26
+	Sc
		544183 HCH1_YEAST (21-164): 1.16e-43: 149: 25.00		HSC82_YEAST (13-724): 0: 922: 60.22