Protein: SRPK3
SRSF protein kinase 3 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1) (Serine/arginine-rich protein-specific kinase 3) (SR-protein-specific kinase 3) (Serine/threonine-protein kinase 23)

Gene: SRPK3
Organism: Homo sapiens
Interactions: 192
UniProt ID: Q9UPE1

Gene Ontology (top 5):
GO:0000245 - spliceosomal complex assembly
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1109242

PRP4K
Serine/threonine-protein kinase PRP4 homolog

3

20

High-throughput

0.871

High

1402641

SRPK1
SRSF protein kinase 1

2

18

High-throughput

0.849

High

473185

RU17
U1 small nuclear ribonucleoprotein 70 kDa

2

20

High-throughput

0.811

High

478259

SNRPA
U1 small nuclear ribonucleoprotein A

2

20

High-throughput

0.811

High

1130884

RRP5
Protein RRP5 homolog

2

9

High-throughput

0.811

High

841501

RBM34
RNA-binding protein 34

2

20

High-throughput

0.726

High

1127247

RBM39
RNA-binding protein 39

2

20

High-throughput

0.726

High

1451039

RBM28
RNA-binding protein 28

2

19

High-throughput

0.726

High

175804

SR140
U2 snRNP-associated SURP motif-containing protein

1

18

High-throughput

0.691

High

214978

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

14

High-throughput

0.691

High

326391

SCAF4
SR-related and CTD-associated factor 4

1

4

High-throughput

0.691

High

620657

NUCL
Nucleolin

1

17

High-throughput

0.691

High

685777

U2AF2
Splicing factor U2AF 65 kDa subunit

1

20

High-throughput

0.691

High

794668

RBMX
RNA-binding motif protein, X chromosome

1

20

High-throughput

0.691

High

889680

CLK2
Dual specificity protein kinase CLK2

1

17

High-throughput

0.691

High

891888

GSK3B
Glycogen synthase kinase-3 beta

1

20

High-throughput

0.691

High

897426

CDK7
Cyclin-dependent kinase 7

1

19

High-throughput

0.691

High

910734

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

19

High-throughput

0.691

High

943738

PRD15
PR domain zinc finger protein 15

1

5

High-throughput

0.691

High

1006798

SRPK2
SRSF protein kinase 2

1

18

High-throughput

0.691

High

1016670

SRSF3
Serine/arginine-rich splicing factor 3

1

20

High-throughput

0.691

High

1029574

SRSF2
Serine/arginine-rich splicing factor 2

1

20

High-throughput

0.691

High

1051535

SRS11
Serine/arginine-rich splicing factor 11

1

15

High-throughput

0.691

High

1061210

SRSF1
Serine/arginine-rich splicing factor 1

1

20

High-throughput

0.691

High

1062154

SRSF4
Serine/arginine-rich splicing factor 4

1

20

High-throughput

0.691

High

1111898

TRA2A
Transformer-2 protein homolog alpha

1

20

High-throughput

0.691

High

1119722

CDK13
Cyclin-dependent kinase 13

1

19

High-throughput

0.691

High

1134087

ZN638
Zinc finger protein 638

1

14

High-throughput

0.691

High

1148576

SF3B4
Splicing factor 3B subunit 4

1

20

High-throughput

0.691

High

1287703

RBM23
Probable RNA-binding protein 23

1

20

High-throughput

0.691

High

1383177

LRC59
Leucine-rich repeat-containing protein 59

1

11

High-throughput

0.691

High

1387476

MSI2H
RNA-binding protein Musashi homolog 2

1

20

High-throughput

0.691

High

1418643

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

20

High-throughput

0.691

High

1430789

GZF1
GDNF-inducible zinc finger protein 1

1

7

High-throughput

0.691

High

1461170

RALY
RNA-binding protein Raly

1

14

High-throughput

0.691

High

1434936

CCD86
Coiled-coil domain-containing protein 86

3

2

High-throughput

0.675

High

346505

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

18

High-throughput

0.628

High

480353

RU1C
U1 small nuclear ribonucleoprotein C

2

5

High-throughput

0.628

High

855259

NOP2
28S rRNA

2

2

High-throughput

0.628

High

938422

NH2L1
NHP2-like protein 1

2

5

High-throughput

0.628

High

1112226

KRR1
KRR1 small subunit processome component homolog

2

2

High-throughput

0.628

High

1117712

NOG2
Nucleolar GTP-binding protein 2

2

4

High-throughput

0.628

High

1130530

RRP1B
Ribosomal RNA processing protein 1 homolog B

2

13

High-throughput

0.628

High

1245527

CC137
Coiled-coil domain-containing protein 137

2

1

High-throughput

0.628

High

1274063

PHF5A
PHD finger-like domain-containing protein 5A

2

3

High-throughput

0.628

High

1351085

DDX54
ATP-dependent RNA helicase DDX54

2

20

High-throughput

0.628

High

1428589

DDX24
ATP-dependent RNA helicase DDX24

2

20

High-throughput

0.628

High

1028727

U2AF1
Splicing factor U2AF 35 kDa subunit

1

8

High-throughput

0.618

High

1099308

SRSF5
Serine/arginine-rich splicing factor 5

1

20

High-throughput

0.618

High

1099604

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.618

High

1394023

SPF45
Splicing factor 45

1

20

High-throughput

0.618

High

1460124

PUF60
Poly(U)-binding-splicing factor PUF60

1

20

High-throughput

0.618

High

462050

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

468921

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

923375

MK12
Mitogen-activated protein kinase 12

1

18

High-throughput

0.618

High

615457

SON
Protein SON

3

20

High-throughput

0.616

High

1314280

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

3

5

High-throughput

0.616

High

1407739

EBP2
Probable rRNA-processing protein EBP2

3

2

High-throughput

0.616

High

290797

SURF6
Surfeit locus protein 6

2

3

High-throughput

0.574

High

301263

RL1D1
Ribosomal L1 domain-containing protein 1

2

4

High-throughput

0.574

High

1140053

RRS1
Ribosome biogenesis regulatory protein homolog

2

2

High-throughput

0.574

High

1148194

PUM3
Pumilio homolog 3

2

12

High-throughput

0.574

High

1351504

BRX1
Ribosome biogenesis protein BRX1 homolog

2

9

High-throughput

0.574

High

1356054

NOC3L
Nucleolar complex protein 3 homolog

2

4

High-throughput

0.574

High

1411827

LLPH
Protein LLP homolog

2

1

High-throughput

0.574

High

1435624

RPF2
Ribosome production factor 2 homolog

2

2

High-throughput

0.574

High

1446688

LUC7L
Putative RNA-binding protein Luc7-like 1

2

15

High-throughput

0.574

High

1462455

RRP15
RRP15-like protein

2

2

High-throughput

0.574

High

1360255

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

1

10

Small-scale

0.553

High

1462458

CHTOP
Chromatin target of PRMT1 protein

2

3

High-throughput

0.549

High

123875

MYO1C
Unconventional myosin-Ic

1

18

High-throughput

0.536

High

141169

NOP56
Nucleolar protein 56

1

3

High-throughput

0.536

High

183101

NKRF
NF-kappa-B-repressing factor

1

3

High-throughput

0.536

High

188549

NVL
Nuclear valosin-containing protein-like

1

6

High-throughput

0.536

High

207681

DHX15
ATP-dependent RNA helicase DHX15

1

10

High-throughput

0.536

High

228000

MYO1B
Unconventional myosin-Ib

1

15

High-throughput

0.536

High

258003

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

3

High-throughput

0.536

High

287195

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

18

High-throughput

0.536

High

321695

PRP6
Pre-mRNA-processing factor 6

1

10

High-throughput

0.536

High

330527

LC7L3
Luc7-like protein 3

1

16

High-throughput

0.536

High

355620

NSD2
Histone-lysine N-methyltransferase NSD2

1

7

High-throughput

0.536

High

403038

ANXA1
Annexin A1

1

3

High-throughput

0.536

High

542697

TOP2A
DNA topoisomerase 2-alpha

1

4

High-throughput

0.536

High

574516

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

8

High-throughput

0.536

High

596424

H12
Histone H1.2

1

12

High-throughput

0.536

High

599907

YBOX3
Y-box-binding protein 3

1

12

High-throughput

0.536

High

616051

RL17
Large ribosomal subunit protein uL22

1

3

High-throughput

0.536

High

649455

H1T
Histone H1t

1

12

High-throughput

0.536

High

686523

RL13
Large ribosomal subunit protein eL13

1

7

High-throughput

0.536

High

720897

KPYR
Pyruvate kinase PKLR

1

5

High-throughput

0.536

High

769805

RFC4
Replication factor C subunit 4

1

7

High-throughput

0.536

High

824426

RL13A
Large ribosomal subunit protein uL13

1

2

High-throughput

0.536

High

911432

IMA5
Importin subunit alpha-5

1

9

High-throughput

0.536

High

923649

TTC3
E3 ubiquitin-protein ligase TTC3

1

10

High-throughput

0.536

High

935653

MFAP1
Microfibrillar-associated protein 1

1

3

High-throughput

0.536

High

940202

RRP1
Ribosomal RNA processing protein 1 homolog A

1

7

High-throughput

0.536

High

960947

RL15
Large ribosomal subunit protein eL15

1

3

High-throughput

0.536

High

961892

RL37A
Large ribosomal subunit protein eL43

1

1

High-throughput

0.536

High

974083

RUXF
Small nuclear ribonucleoprotein F

1

7

High-throughput

0.536

High

974492

SMD1
Small nuclear ribonucleoprotein Sm D1

1

9

High-throughput

0.536

High

976027

RL7A
Large ribosomal subunit protein eL8

1

5

High-throughput

0.536

High

1025774

PURA
Transcriptional activator protein Pur-alpha

1

8

High-throughput

0.536

High

1043784

CEBPZ
CCAAT/enhancer-binding protein zeta

1

2

High-throughput

0.536

High

1062719

DHX9
ATP-dependent RNA helicase A

1

16

High-throughput

0.536

High

1066816

NCBP1
Nuclear cap-binding protein subunit 1

1

5

High-throughput

0.536

High

1086563

TROP
Trophinin

1

7

High-throughput

0.536

High

1112351

PWP1
Periodic tryptophan protein 1 homolog

1

20

High-throughput

0.536

High

1131001

BMS1
Ribosome biogenesis protein BMS1 homolog

1

4

High-throughput

0.536

High

1146541

TTF1
Transcription termination factor 1

1

7

High-throughput

0.536

High

1199481

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

17

High-throughput

0.536

High

1214829

ATD3B
ATPase family AAA domain-containing protein 3B

1

12

High-throughput

0.536

High

1247301

WDR74
WD repeat-containing protein 74

1

20

High-throughput

0.536

High

1271611

DHX30
ATP-dependent RNA helicase DHX30

1

15

High-throughput

0.536

High

1275756

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

8

High-throughput

0.536

High

1291282

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

11

High-throughput

0.536

High

1314734

SRRM1
Serine/arginine repetitive matrix protein 1

1

20

High-throughput

0.536

High

1316603

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

15

High-throughput

0.536

High

1332862

PR38A
Pre-mRNA-splicing factor 38A

1

5

High-throughput

0.536

High

1357103

CATIN
Splicing factor Cactin

1

2

High-throughput

0.536

High

1392267

DDX27
Probable ATP-dependent RNA helicase DDX27

1

20

High-throughput

0.536

High

1404512

CDC5L
Cell division cycle 5-like protein

1

20

High-throughput

0.536

High

1405511

SCAFB
Protein SCAF11

1

19

High-throughput

0.536

High

1410779

MBB1A
Myb-binding protein 1A

1

1

High-throughput

0.536

High

1415576

GNL3
Guanine nucleotide-binding protein-like 3

1

4

High-throughput

0.536

High

1417211

SRRT
Serrate RNA effector molecule homolog

1

4

High-throughput

0.536

High

1419739

GTPB4
GTP-binding protein 4

1

5

High-throughput

0.536

High

1428495

REXO4
RNA exonuclease 4

1

2

High-throughput

0.536

High

1429645

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.536

High

1429822

XRN2
5'-3' exoribonuclease 2

1

3

High-throughput

0.536

High

1430406

DDX47
Probable ATP-dependent RNA helicase DDX47

1

20

High-throughput

0.536

High

1436306

DDX31
ATP-dependent DNA helicase DDX31

1

20

High-throughput

0.536

High

1438898

MOV10
Helicase MOV-10

1

5

High-throughput

0.536

High

1446789

SSF1
Suppressor of SWI4 1 homolog

1

2

High-throughput

0.536

High

1447241

EXOS5
Exosome complex component RRP46

1

1

High-throughput

0.536

High

1447857

DDX21
Nucleolar RNA helicase 2

1

20

High-throughput

0.536

High

1448788

RNC
Ribonuclease 3

1

7

High-throughput

0.536

High

1450739

DDX18
ATP-dependent RNA helicase DDX18

1

20

High-throughput

0.536

High

1451829

LYAR
Cell growth-regulating nucleolar protein

1

3

High-throughput

0.536

High

1452369

DDX56
Probable ATP-dependent RNA helicase DDX56

1

20

High-throughput

0.536

High

1458248

TFP11
Tuftelin-interacting protein 11

1

1

High-throughput

0.536

High

1461038

MRT4
mRNA turnover protein 4 homolog

1

7

High-throughput

0.536

High

1461246

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

20

High-throughput

0.536

High

1462450

SRRM2
Serine/arginine repetitive matrix protein 2

1

20

High-throughput

0.536

High

1462454

EXOS1
Exosome complex component CSL4

1

1

High-throughput

0.536

High

1462457

NOC2L
Nucleolar complex protein 2 homolog

1

3

High-throughput

0.536

High

1462459

LAS1L
Ribosomal biogenesis protein LAS1L

1

2

High-throughput

0.536

High

1462460

PAXB1
PAX3- and PAX7-binding protein 1

1

1

High-throughput

0.536

High

1032267

EXOSX
Exosome complex component 10

1

0

High-throughput

0.513

High

1151335

ZNHI3
Zinc finger HIT domain-containing protein 3

1

0

High-throughput

0.513

High

1416255

SF3B5
Splicing factor 3B subunit 5

1

0

High-throughput

0.513

High

1437591

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

1

0

High-throughput

0.513

High

134412

RPOM
DNA-directed RNA polymerase, mitochondrial

1

2

High-throughput

0.489

High

208428

RRP8
Ribosomal RNA-processing protein 8

1

2

High-throughput

0.489

High

338215

NSA2
Ribosome biogenesis protein NSA2 homolog

1

2

High-throughput

0.489

High

884274

SRP09
Signal recognition particle 9 kDa protein

1

1

High-throughput

0.489

High

1085731

TBL3
Transducin beta-like protein 3

1

20

High-throughput

0.489

High

1193407

GLYR1
Cytokine-like nuclear factor N-PAC

1

6

High-throughput

0.489

High

1199296

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

1

High-throughput

0.489

High

1231690

RL7L
Ribosomal protein uL30-like

1

3

High-throughput

0.489

High

1332258

KRI1
Protein KRI1 homolog

1

3

High-throughput

0.489

High

1341170

WDR36
WD repeat-containing protein 36

1

13

High-throughput

0.489

High

1366470

RT31
Small ribosomal subunit protein mS31

1

1

High-throughput

0.489

High

1398219

RIPR3
RIPOR family member 3

1

1

High-throughput

0.489

High

1411215

CHOLN
Protein cholesin

1

2

High-throughput

0.489

High

1417590

MAK16
Protein MAK16 homolog

1

1

High-throughput

0.489

High

1437304

RPF1
Ribosome production factor 1

1

3

High-throughput

0.489

High

1446304

NOP10
H/ACA ribonucleoprotein complex subunit 3

1

1

High-throughput

0.489

High

1449874

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

18

High-throughput

0.489

High

1450951

NLE1
Notchless protein homolog 1

1

16

High-throughput

0.489

High

1452194

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

2

High-throughput

0.489

High

1453468

NOP53
Ribosome biogenesis protein NOP53

1

2

High-throughput

0.489

High

1459779

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.489

High

1462379

DIM1
Dimethyladenosine transferase

1

2

High-throughput

0.489

High

1462451

NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

1

2

High-throughput

0.489

High

1462453

LC7L2
Putative RNA-binding protein Luc7-like 2

1

17

High-throughput

0.489

High

1462461

RT18B
Small ribosomal subunit protein mS40

1

2

High-throughput

0.489

High

1462456

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

730958

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

810460

RL3
Large ribosomal subunit protein uL3

1

4

High-throughput

0.479

High

960302

RL26
Large ribosomal subunit protein uL24

1

3

High-throughput

0.479

High

972131

1433E
14-3-3 protein epsilon

1

16

High-throughput

0.479

High

1146871

PCBP1
Poly(rC)-binding protein 1

1

15

High-throughput

0.479

High

1218699

OTU1
Ubiquitin thioesterase OTU1

1

2

High-throughput

0.479

High

1380788

RL36L
Ribosomal protein eL42-like

1

2

High-throughput

0.479

High

1462452

TR150
Thyroid hormone receptor-associated protein 3

1

20

High-throughput

0.479

High

942959

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

18

High-throughput

0.445

High

1462397

RL26L
Ribosomal protein uL24-like

1

3

High-throughput

0.437

High

71628

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

12

High-throughput

0.407

High

244422

NPA1P
Nucleolar pre-ribosomal-associated protein 1

1

0

High-throughput

0.279

Low

1381075

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

1

0

High-throughput

0.279

Low

1439556

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

1

0

High-throughput

0.279

Low

590959

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025