HitPredict

Interactor 1: FARP2 (O94887)
FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)
Gene: FARP2

Interactor 2: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36976175
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, RhoGEF~fn3
Common GO terms	GO:0007155 - cell adhesion GO:0030316 - osteoclast differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1054 Hs			1 976
+	Hs
		710505 E41L5_HUMAN (7-546): 3.08e-119: 385: 24.55		EPHA2_HUMAN (1-976): 0: 1124: 100.00
+	Hs
		710493 E41L1_HUMAN (4-537): 1.46e-114: 377: 28.60		EPHA2_HUMAN (1-976): 0: 1124: 100.00
+	Hs
		217389 E41L2_HUMAN (5-493): 1.28e-109: 366: 30.92		EPHA2_HUMAN (1-976): 0: 1124: 100.00
+	Hs
		710487 E41LB_HUMAN (33-590): 1.75e-110: 366: 24.69		EPHA2_HUMAN (1-976): 0: 1124: 100.00
+	Hs
		710506 E41LA_HUMAN (41-555): 1.01e-104: 345: 24.05		EPHA2_HUMAN (1-976): 0: 1124: 100.00
+	Hs
		320534 FARP2_HUMAN (1-1054): 0: 850: 100.00		FGFR3_HUMAN (381-889): 3.37e-136: 430: 24.65
+	Hs
		320526 FARP2_HUMAN (1-1054): 0: 850: 100.00		LYN_HUMAN (607-879): 2.07e-64: 228: 42.91
+	Hs
		463861 FARP1_HUMAN (1-1039): 0: 737: 52.90		LYN_HUMAN (607-879): 2.07e-64: 228: 42.91
+	Hs
		720329 E41L5_HUMAN (7-546): 3.08e-119: 385: 24.55		UFO_HUMAN (294-911): 1.96e-144: 454: 24.15
+	Hs
		538887 EPB41_HUMAN (3-545): 1.47e-115: 379: 28.75		UFO_HUMAN (294-911): 1.96e-144: 454: 24.15
+	Hs
		720325 E41L1_HUMAN (4-537): 1.46e-114: 377: 28.60		UFO_HUMAN (294-911): 1.96e-144: 454: 24.15
+	Hs
		217392 E41L2_HUMAN (5-493): 1.28e-109: 366: 30.92		UFO_HUMAN (294-911): 1.96e-144: 454: 24.15
+	Hs
		538874 EPB41_HUMAN (3-545): 1.47e-115: 379: 28.75		FGFR3_HUMAN (381-889): 3.37e-136: 430: 24.65
+	Hs
		439646 PTN3_HUMAN (25-512): 2.66e-101: 341: 24.05		INSR_HUMAN (281-911): 2.91e-136: 444: 24.78
+	Hs
		463780 E41L5_HUMAN (7-546): 3.08e-119: 385: 24.55		LYN_HUMAN (607-879): 2.07e-64: 228: 42.91
+	Hs
		463297 EPB41_HUMAN (3-545): 1.47e-115: 379: 28.75		LYN_HUMAN (607-879): 2.07e-64: 228: 42.91
+	Hs
		463855 E41L3_HUMAN (39-514): 3.07e-113: 378: 30.96		LYN_HUMAN (607-879): 2.07e-64: 228: 42.91
+	Hs
		463768 E41L1_HUMAN (4-537): 1.46e-114: 377: 28.60		LYN_HUMAN (607-879): 2.07e-64: 228: 42.91
+	Hs
		217371 E41L2_HUMAN (5-493): 1.28e-109: 366: 30.92		LYN_HUMAN (607-879): 2.07e-64: 228: 42.91
+	Hs
		463764 E41LB_HUMAN (33-590): 1.75e-110: 366: 24.69		LYN_HUMAN (607-879): 2.07e-64: 228: 42.91