HitPredict

Interactor 1: TTC4 (O95801)
Tetratricopeptide repeat protein 4 (TPR repeat protein 4)
Gene: TTC4

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.648

Property	Details
Experiments	25036637, 18320024
Identification Methods	affinity chromatography technology, lexa b52 complementation, anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006457 - protein folding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 387 Hs			1 724
+	Hs
		111932 TTC4_HUMAN (1-387): 1.31e-88: 274: 100.00		K9JA46_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		323392 TTC4_HUMAN (1-387): 1.31e-88: 274: 100.00		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Dm
		51550 TTC4_DROME (2-382): 3.22e-63: 209: 30.45		HSP83_DROME (10-724): 0: 1057: 78.46
+	Hs
		438336 UN45B_HUMAN (75-276): 2.24e-41: 157: 23.08		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438136 FKBP5_HUMAN (10-255): 2.21e-42: 155: 17.56		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Mm
		513680 PPP5_MOUSE (63-268): 6.6e-41: 152: 16.51		HS90B_MOUSE (1-724): 0: 1089: 99.59
+	Hs
		438021 PPP5_HUMAN (63-268): 4.43e-41: 153: 16.99		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		111940 UN45B_HUMAN (75-276): 2.24e-41: 157: 23.08		K9JA46_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		432038 UN45B_HUMAN (75-276): 2.24e-41: 157: 23.08		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		111937 FKBP5_HUMAN (10-255): 2.21e-42: 155: 17.56		K9JA46_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431818 FKBP5_HUMAN (10-255): 2.21e-42: 155: 17.56		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		111935 PPP5_HUMAN (63-268): 4.43e-41: 153: 16.99		K9JA46_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431681 PPP5_HUMAN (63-268): 4.43e-41: 153: 16.99		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Mm
		432427 PPP5_MOUSE (63-268): 6.6e-41: 152: 16.51		HS90A_MOUSE (1-724): 0: 1068: 84.31
+	Hs
		323417 TTC4_HUMAN (1-387): 1.31e-88: 274: 100.00		H90B3_HUMAN (1-724): 0: 815: 75.83
+	Sc
		366048 CNS1_YEAST (23-358): 5e-41: 150: 22.06		HSP82_YEAST (12-724): 0: 927: 61.26
+	Mm
		435924 PPP5_MOUSE (63-268): 6.6e-41: 152: 16.51		ENPL_MOUSE (3-724): 0: 920: 45.29
+	Hs
		1123420 UN45B_HUMAN (75-276): 2.24e-41: 157: 23.08		H90B4_HUMAN (25-596): 0: 639: 71.85
+	Hs
		858632 PPP5_HUMAN (63-268): 4.43e-41: 153: 16.99		H90B4_HUMAN (25-596): 0: 639: 71.85
+	Hs
		1162510 UN45B_HUMAN (75-276): 2.24e-41: 157: 23.08		Q6PK50_HUMAN (1-350): 0: 618: 99.71