HitPredict

Interactor 1: TTC4 (O95801)
Tetratricopeptide repeat protein 4 (TPR repeat protein 4)
Gene: TTC4

Interactor 2: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.526

Property	Details
Experiments	18320024
Identification Methods	lexa b52 complementation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006457 - protein folding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 387 Hs			1 646
+	Dm
		51549 TTC4_DROME (2-382): 3.22e-63: 209: 30.45		HSP71_DROME (5-646): 0: 927: 74.81
+	Hs
		504028 FKBP5_HUMAN (10-255): 2.21e-42: 155: 17.56		HSP7C_HUMAN (1-646): 0: 967: 100.00
+	Hs
		713959 FKBP5_HUMAN (10-255): 2.21e-42: 155: 17.56		HS71L_HUMAN (2-646): 0: 966: 82.48
+	Hs
		503738 PPP5_HUMAN (63-268): 4.43e-41: 153: 16.99		HSP7C_HUMAN (1-646): 0: 967: 100.00
+	Mm
		926131 PPP5_MOUSE (63-268): 6.6e-41: 152: 16.51		HSP7C_MOUSE (1-646): 0: 967: 99.85
+	Mm
		926173 CHIP_MOUSE (55-365): 2.66e-39: 143: 15.24		HSP7C_MOUSE (1-646): 0: 967: 99.85
+	Hs
		504954 CHIP_HUMAN (74-365): 9.58e-39: 142: 15.88		HSP7C_HUMAN (1-646): 0: 967: 100.00
+	Hs
		503930 FKBP4_HUMAN (39-247): 3.08e-37: 141: 16.36		HSP7C_HUMAN (1-646): 0: 967: 100.00
+	Hs
		564043 PPP5_HUMAN (63-268): 4.43e-41: 153: 16.99		HSP76_HUMAN (6-646): 0: 955: 77.54
+	Hs
		714095 CHIP_HUMAN (74-365): 9.58e-39: 142: 15.88		HS71L_HUMAN (2-646): 0: 966: 82.48
+	Mm
		571871 CHIP_MOUSE (55-365): 2.66e-39: 143: 15.24		HS71B_MOUSE (1-646): 0: 957: 83.90
+	Hs
		564209 CHIP_HUMAN (74-365): 9.58e-39: 142: 15.88		HSP76_HUMAN (6-646): 0: 955: 77.54
+	Hs
		871653 UN45B_HUMAN (75-276): 2.24e-41: 157: 23.08		HSP72_HUMAN (2-646): 0: 940: 85.47
+	Hs
		564151 SGTB_HUMAN (10-200): 4.73e-38: 140: 23.04		HSP76_HUMAN (6-646): 0: 955: 77.54
+	Hs
		483811 CHIP_HUMAN (74-365): 9.58e-39: 142: 15.88		HS71B_HUMAN (1-646): 0: 948: 84.37
+	At
		612321 OE64C_ARATH (56-196): 5.12e-36: 140: 27.66		HS701_ARATH (3-646): 0: 944: 76.35
+	Ce
		108031 G5EG62_CAEEL (74-248): 1.75e-37: 146: 27.62		HSP1_CAEEL (1-646): 0: 937: 84.39
+	Hs
		871829 CHIP_HUMAN (74-365): 9.58e-39: 142: 15.88		HSP72_HUMAN (2-646): 0: 940: 85.47
+	Hs
		174578 OGT1_HUMAN (55-327): 5.32e-26: 112: 12.45		HSP7C_HUMAN (1-646): 0: 967: 100.00
+	At
		99225 OE64M_ARATH (56-188): 1.17e-28: 119: 29.32		HS701_ARATH (3-646): 0: 944: 76.35