HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: HS904 (Q58FG1)
Putative heat shock protein HSP 90-alpha A4 (Heat shock 90 kDa protein 1 alpha-like 2) (Heat shock protein 90-alpha D) (Heat shock protein 90Ad)
Gene: HSP90AA4P

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	33961781
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 418
+	Hs
		1123554 LATS2_HUMAN (13-1121): 0: 751: 49.61		HS904_HUMAN (1-418): 0: 547: 100.00
+	Hs
		325599 LATS1_HUMAN (1-1130): 0: 934: 100.00		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		1123562 AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54		HS904_HUMAN (1-418): 0: 547: 100.00
+	Hs
		432293 LATS2_HUMAN (13-1121): 0: 751: 49.61		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		438558 LATS2_HUMAN (13-1121): 0: 751: 49.61		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Sc
		366698 CBK1_YEAST (397-1091): 2.99e-167: 514: 30.07		HSP82_YEAST (111-258): 1.18e-42: 160: 46.62
+	Sc
		544196 CBK1_YEAST (397-1091): 2.99e-167: 514: 30.07		HSC82_YEAST (111-258): 2.14e-42: 160: 46.62
+	Hs
		432381 ST38L_HUMAN (627-1089): 2.37e-167: 503: 40.82		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		431870 STK38_HUMAN (622-1089): 5.96e-165: 497: 40.17		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		438637 ST38L_HUMAN (627-1089): 2.37e-167: 503: 40.82		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		438188 STK38_HUMAN (622-1089): 5.96e-165: 497: 40.17		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Sc
		365836 KPC1_YEAST (45-1086): 3.02e-152: 486: 15.15		HSP82_YEAST (111-258): 1.18e-42: 160: 46.62
+	Hs
		1123464 AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54		H90B3_HUMAN (2-153): 1.55e-48: 175: 50.66
+	Hs
		432376 AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Mm
		432411 AKT1_MOUSE (595-1081): 6.22e-141: 435: 24.50		HS90A_MOUSE (96-271): 1.07e-44: 167: 50.85
+	Hs
		438633 AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Bt
		964601 AKT1_BOVIN (595-1081): 3.57e-142: 439: 24.70		HS90B_BOVIN (96-256): 4.94e-41: 156: 51.85
+	Hs
		538446 AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54		ENPL_HUMAN (96-407): 1.36e-36: 144: 26.90
+	Hs
		1123447 AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54		H90B4_HUMAN (112-275): 1.78e-26: 112: 42.42
+	Hs
		1162538 AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54		Q6PK50_HUMAN (96-157): 2.21e-13: 72.7: 61.91