HitPredict

Interactor 1: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Interactor 2: MK06 (Q16659)
Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK)
Gene: MAPK6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26972000
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032991 - protein-containing complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 2799 Hs			1 721
+	Hs
		325694 UBR5_HUMAN (1-2799): 0: 3949: 100.00		MK01_HUMAN (14-354): 1.99e-137: 410: 42.57
+	Hs
		325689 UBR5_HUMAN (1-2799): 0: 3949: 100.00		MK03_HUMAN (8-360): 1.59e-133: 400: 41.41
+	Hs
		1161129 HUWE1_HUMAN (2499-2798): 1.3e-100: 366: 27.27		MK06_HUMAN (1-721): 0: 640: 100.00
+	Hs
		861623 NEDD4_HUMAN (2446-2796): 8.66e-120: 416: 23.98		MK14_HUMAN (4-354): 7.83e-133: 398: 35.31
+	Hs
		1025288 NED4L_HUMAN (2187-2796): 1.96e-123: 418: 18.20		CDK3_HUMAN (17-334): 5.67e-130: 388: 31.48
+	Hs
		703634 HUWE1_HUMAN (2499-2798): 1.3e-100: 366: 27.27		MK01_HUMAN (14-354): 1.99e-137: 410: 42.57
+	Hs
		1050433 UBE3A_HUMAN (2529-2799): 7.91e-20: 99.4: 29.93		MK06_HUMAN (1-721): 0: 640: 100.00
+	Hs
		703547 UBE3A_HUMAN (2529-2799): 7.91e-20: 99.4: 29.93		MK01_HUMAN (14-354): 1.99e-137: 410: 42.57