HitPredict

Interactor 1: BCL10 (O95999)
B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10)
Gene: BCL10

Interactor 2: CAR14 (Q9BXL6)
Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2)
Gene: CARD14

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.825

Property	Details
Experiments	11278692, 27071417
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	CARD~CARD
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0050700 - CARD domain binding GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 1004
+	Hs
		330286 BCL10_HUMAN (1-233): 5.01e-155: 431: 100.00		CARD9_HUMAN (15-460): 1.54e-155: 472: 30.87
+	Hs
		330278 BCL10_HUMAN (1-233): 5.01e-155: 431: 100.00		CAR10_HUMAN (17-1000): 5.55e-92: 317: 26.15
+	Hs
		330281 BCL10_HUMAN (1-233): 5.01e-155: 431: 100.00		CAR11_HUMAN (13-1001): 5.09e-90: 314: 25.64
+	Mm
		57159 BCL10_MOUSE (1-233): 5.97e-156: 433: 90.99		CARD9_MOUSE (15-471): 1.23e-91: 304: 30.09
+	Mm
		1208618 BCL10_MOUSE (1-233): 5.97e-156: 433: 90.99		CAR11_MOUSE (13-1001): 2.2e-80: 286: 24.56
+	Mm
		885970 BCL10_MOUSE (1-233): 5.97e-156: 433: 90.99		CAR10_MOUSE (12-316): 3.5e-10: 66.2: 11.71