HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31248990, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Chromo~PHD
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1365 Hs			1 183
+	Hs
		1027243 NSD3_HUMAN (116-1340): 0: 758: 45.19		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		1317731 NSD3_HUMAN (116-1340): 0: 758: 45.19		V9HWG0_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		800517 NSD3_HUMAN (116-1340): 0: 758: 45.19		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		949878 NSD3_HUMAN (116-1340): 0: 758: 45.19		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Dm
		399018 NSD_DROME (44-1238): 7.02e-141: 468: 24.59		HP1_DROME (9-180): 2.12e-45: 150: 38.73
+	Hs
		203674 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		1027262 SUV92_HUMAN (826-1203): 4.69e-72: 249: 20.84		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Mm
		222468 SUV91_MOUSE (830-1202): 5.62e-72: 249: 20.69		Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00
+	Mm
		222460 SUV91_MOUSE (830-1202): 5.62e-72: 249: 20.69		CBX3_MOUSE (1-183): 4.67e-71: 214: 99.45
+	Hs
		203638 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		203823 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		V9HWG0_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		1331984 SUV92_HUMAN (826-1203): 4.69e-72: 249: 20.84		V9HWG0_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Mm
		222467 SUV91_MOUSE (830-1202): 5.62e-72: 249: 20.69		CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89
+	Hs
		800527 SUV92_HUMAN (826-1203): 4.69e-72: 249: 20.84		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		203662 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Mm
		222462 SUV91_MOUSE (830-1202): 5.62e-72: 249: 20.69		CBX1_MOUSE (36-180): 1.02e-53: 170: 71.33
+	Hs
		949887 SUV92_HUMAN (826-1203): 4.69e-72: 249: 20.84		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Hs
		203597 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		SUV91_HUMAN (3-179): 4.73e-40: 141: 16.20
+	Hs
		123140 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52
+	Hs
		327863 SUV92_HUMAN (826-1203): 4.69e-72: 249: 20.84		CBX7_HUMAN (21-181): 5.6e-29: 109: 22.78