Interactor 1: M3K6 (O95382)
Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2)
Gene: MAP3K6
Interactor 2: AAPK2 (P54646)
5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31)
Gene: PRKAA2
Species: Homo sapiens
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.47 | 1.00 | 0.691 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 20562859 |
| Identification Methods | affinity chromatography technology, anti tag coimmunoprecipitation |
| Interaction Type | physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | ASK_PH~Pkinase, MAP3K_TRAF_bd~Pkinase, AdenylateSensor~Pkinase, AMPK_alpha_AID~Pkinase, Pkinase~Pkinase |
| Common GO terms | GO:0005524 - ATP binding GO:0006468 - protein phosphorylation GO:0007165 - signal transduction GO:0106310 - protein serine kinase activity |
| Homologous interactions | 18 |
Homologous interactions
Color coding for hit scores 
|
|
|||||||||||||
| + | Hs |   |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Sc | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | Rn | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | Sc | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | Mm | |
|
|||||||||||
Service provided by Combinatics, Japan
Last updated: 11Aug2025
