HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: CBLB (Q13191)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0017124 - SH3 domain binding GO:0050852 - T cell receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 982
+	Hs
		69208 A9UF07_HUMAN (25-1130): 0: 945: 99.73		CBLB_HUMAN (1-982): 0: 877: 100.00
+	Hs
		337348 ABL1_HUMAN (1-1130): 0: 984: 100.00		CBL_HUMAN (25-976): 0: 675: 47.10
+	Hs
		69201 A9UF07_HUMAN (25-1130): 0: 945: 99.73		CBL_HUMAN (25-976): 0: 675: 47.10
+	Mm
		337618 ABL1_MOUSE (1-1130): 0: 901: 85.00		CBL_MOUSE (25-976): 0: 674: 47.47
+	Hs
		610281 ABL2_HUMAN (10-1130): 0: 775: 52.62		CBL_HUMAN (25-976): 0: 675: 47.10
+	Hs
		522956 SRC_HUMAN (13-510): 0: 547: 38.58		CBLB_HUMAN (1-982): 0: 877: 100.00
+	Hs
		412170 FYN_HUMAN (18-510): 0: 543: 38.64		CBLB_HUMAN (1-982): 0: 877: 100.00
+	Hs
		433339 YES_HUMAN (5-510): 3.73e-179: 537: 39.42		CBLB_HUMAN (1-982): 0: 877: 100.00
+	Rn
		1144046 FYN_RAT (18-510): 0: 541: 38.64		CBLB_RAT (1-982): 0: 845: 90.84
+	Hs
		522778 SRC_HUMAN (13-510): 0: 547: 38.58		CBL_HUMAN (25-976): 0: 675: 47.10
+	Mm
		403415 SRC_MOUSE (13-510): 0: 545: 38.19		CBL_MOUSE (25-976): 0: 674: 47.47
+	Hs
		412013 FYN_HUMAN (18-510): 0: 543: 38.64		CBL_HUMAN (25-976): 0: 675: 47.10
+	Mm
		610554 FYN_MOUSE (18-510): 0: 542: 38.64		CBL_MOUSE (25-976): 0: 674: 47.47
+	Hs
		433254 YES_HUMAN (5-510): 3.73e-179: 537: 39.42		CBL_HUMAN (25-976): 0: 675: 47.10
+	Mm
		411917 LCK_MOUSE (9-508): 5.49e-179: 535: 38.30		CBL_MOUSE (25-976): 0: 674: 47.47
+	Hs
		523198 SRC_HUMAN (13-510): 0: 547: 38.58		CBLC_HUMAN (29-497): 0: 585: 44.65
+	Hs
		412405 FYN_HUMAN (18-510): 0: 543: 38.64		CBLC_HUMAN (29-497): 0: 585: 44.65
+	Hs
		433504 YES_HUMAN (5-510): 3.73e-179: 537: 39.42		CBLC_HUMAN (29-497): 0: 585: 44.65
+	Hs
		337335 ABL1_HUMAN (1-1130): 0: 984: 100.00		MUC1_HUMAN (394-976): 7.81e-25: 113: 10.36
+	Hs
		522749 SRC_HUMAN (13-510): 0: 547: 38.58		MUC1_HUMAN (394-976): 7.81e-25: 113: 10.36