HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: DOK1 (Q99704)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
Gene: DOK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.949

Property	Details
Experiments	11071635, 9008161, 22974441, 9822717, 19823681, 10688886
Identification Methods	pull down, affinity chromatography technology, unspecified method, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 481
+	Mm
		337623 ABL1_MOUSE (1-1130): 0: 901: 85.00		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Hs
		789086 ABL2_HUMAN (10-1130): 0: 775: 52.62		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		235031 ABL1_HUMAN (1-1130): 0: 984: 100.00		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Mm
		337639 ABL1_MOUSE (1-1130): 0: 901: 85.00		DOK3_MOUSE (1-458): 4.81e-120: 360: 30.90
+	Mm
		250948 ABL1_MOUSE (1-1130): 0: 901: 85.00		DOK2_MOUSE (2-426): 3.12e-118: 354: 31.31
+	Hs
		523124 SRC_HUMAN (13-510): 0: 547: 38.58		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		433460 YES_HUMAN (5-510): 3.73e-179: 537: 39.42		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		454844 FGR_HUMAN (2-509): 5.33e-178: 533: 38.88		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		442876 HCK_HUMAN (9-508): 5.18e-175: 526: 38.79		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Mm
		250949 SRC_MOUSE (13-510): 0: 545: 38.19		DOK2_MOUSE (2-426): 3.12e-118: 354: 31.31
+	Hs
		235040 SRC_HUMAN (13-510): 0: 547: 38.58		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		235036 FYN_HUMAN (18-510): 0: 543: 38.64		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		235037 YES_HUMAN (5-510): 3.73e-179: 537: 39.42		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		235035 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		151689 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Hs
		412057 FYN_HUMAN (18-510): 0: 543: 38.64		IRS1_HUMAN (6-373): 1.95e-76: 262: 16.33
+	Dm
		1360394 SRC42_DROME (10-508): 0: 541: 39.30		Q9W3R6_DROME (1-256): 8.47e-59: 206: 25.75
+	Mm
		403453 SRC_MOUSE (13-510): 0: 545: 38.19		FRS2_MOUSE (154-464): 4.46e-56: 196: 21.73
+	Hs
		411805 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		FRS2_HUMAN (154-464): 2.53e-54: 191: 21.09
+	Hs
		207290 HCK_HUMAN (9-508): 5.18e-175: 526: 38.79		FRS3_HUMAN (153-432): 4e-52: 185: 20.42