Protein: RPGF4
Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII)

Gene: RPGF4, RAPGEF4
Organism: Homo sapiens
Interactions: 28
UniProt ID: Q8WZA2

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1130385

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.692

High

486043

RAP2A
Ras-related protein Rap-2a

1

20

Small-scale

0.647

High

919656

RAP1A
Ras-related protein Rap-1A

1

20

Small-scale

0.647

High

1264972

SWP70
Switch-associated protein 70

2

10

High-throughput

0.628

High

868651

ATX1
Ataxin-1

2

1

High-throughput

0.620

High

1264971

DEFI6
Differentially expressed in FDCP 6 homolog

2

12

High-throughput

0.606

High

1264968

MERB1
bMERB domain-containing protein 1

2

1

High-throughput

0.590

High

1264973

RIMS2
Regulating synaptic membrane exocytosis protein 2

2

5

Small-scale

0.584

High

240115

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.546

High

234560

DSCAM
Cell adhesion molecule DSCAM

1

4

High-throughput

0.541

High

1020838

TRAF2
TNF receptor-associated factor 2

1

0

High-throughput

0.518

High

791816

HD
Huntingtin

1

1

High-throughput

0.515

High

1199076

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

0

High-throughput

0.513

High

256553

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

1

High-throughput

0.494

High

1264970

MAGT1
Magnesium transporter protein 1

1

0

High-throughput

0.493

High

403297

LA
Lupus La protein

1

0

High-throughput

0.493

High

829040

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.493

High

305112

RIMB1
Peripheral-type benzodiazepine receptor-associated protein 1

1

6

High-throughput

0.481

High

131022

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.479

High

228214

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

1243867

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

998554

ABCC8
ATP-binding cassette sub-family C member 8

1

0

Small-scale

0.458

High

1243132

FXL13
F-box and leucine-rich repeat protein 13

1

0

Small-scale

0.458

High

1199980

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

5

High-throughput

0.445

High

1264969

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

7

High-throughput

0.445

High

1264974

S22A7
Solute carrier family 22 member 7

1

0

High-throughput

0.438

High

1264975

X5D7A4
Benzodiazapine receptor peripheral-associated protein 1 isoform F

1

10

High-throughput

0.417

High

1155812

RADX
RPA-related protein RADX

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024