HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: ABI2 (Q9NYB9)
Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)
Gene: ABI2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.954

Property	Details
Experiments	17101133, 27229929, 12569093, 28514442, 7590236, 33961781
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0017124 - SH3 domain binding GO:0018108 - peptidyl-tyrosine phosphorylation and 1 others more... GO:0070064 - proline-rich region binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 513
+	Hs
		337502 ABL1_HUMAN (1-1130): 0: 984: 100.00		ABI1_HUMAN (1-513): 3.84e-97: 304: 61.00
+	Mm
		337634 ABL1_MOUSE (1-1130): 0: 901: 85.00		ABI1_MOUSE (1-513): 2.82e-100: 312: 60.04
+	Hs
		337590 ABL1_HUMAN (1-1130): 0: 984: 100.00		ASAP1_HUMAN (65-510): 8.77e-43: 165: 14.66
+	Hs
		337333 ABL1_HUMAN (1-1130): 0: 984: 100.00		VAV_HUMAN (276-513): 8.6e-32: 131: 17.86
+	Hs
		789078 ABL2_HUMAN (10-1130): 0: 775: 52.62		ABI1_HUMAN (1-513): 3.84e-97: 304: 61.00
+	Hs
		298944 ABL1_HUMAN (1-1130): 0: 984: 100.00		SRBS2_HUMAN (373-509): 1.11e-16: 85.5: 19.87
+	Hs
		337418 ABL1_HUMAN (1-1130): 0: 984: 100.00		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		789094 ABL2_HUMAN (10-1130): 0: 775: 52.62		ABI2_HUMAN (1-513): 1.82e-91: 290: 100.00
+	Hs
		69206 A9UF07_HUMAN (25-1130): 0: 945: 99.73		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		789066 ABL2_HUMAN (10-1130): 0: 775: 52.62		SRC8_HUMAN (271-507): 2.78e-32: 131: 17.84
+	Hs
		298959 ABL2_HUMAN (10-1130): 0: 775: 52.62		SRBS2_HUMAN (373-509): 1.11e-16: 85.5: 19.87
+	Hs
		789054 ABL2_HUMAN (10-1130): 0: 775: 52.62		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		523060 SRC_HUMAN (13-510): 0: 547: 38.58		ABI1_HUMAN (1-513): 3.84e-97: 304: 61.00
+	Hs
		412258 FYN_HUMAN (18-510): 0: 543: 38.64		ABI1_HUMAN (1-513): 3.84e-97: 304: 61.00
+	Ce
		371307 ABL1_CAEEL (3-1130): 0: 606: 32.11		Q10929_CAEEL (3-508): 2.34e-66: 223: 30.00
+	Dm
		337662 ABL_DROME (38-1092): 0: 583: 39.20		Q9Y0S9_DROME (1-507): 5.88e-73: 240: 34.91
+	Hs
		523197 SRC_HUMAN (13-510): 0: 547: 38.58		ASAP1_HUMAN (65-510): 8.77e-43: 165: 14.66
+	Hs
		522981 SRC_HUMAN (13-510): 0: 547: 38.58		SRC8_HUMAN (271-507): 2.78e-32: 131: 17.84
+	Hs
		411981 FYN_HUMAN (18-510): 0: 543: 38.64		VAV_HUMAN (276-513): 8.6e-32: 131: 17.86
+	Hs
		522887 SRC_HUMAN (13-510): 0: 547: 38.58		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93